PMID- 8782095
OWN - NLM
STAT- MEDLINE
DCOM- 19961024
LR  - 20191101
IS  - 1056-8719 (Print)
IS  - 1056-8719 (Linking)
VI  - 35
IP  - 3
DP  - 1996 Jun
TI  - Assessment of the ear swelling test and the local lymph node assay in hamsters.
PG  - 167-72
AB  - In a hamster model, we compared contact sensitivity to the metal salt, potassium 
      dichromate, to that of oxazolone, a well-known strong sensitizing agent. Using 
      the ear swelling test, originally developed in mice, no significant differences 
      could be observed between animals treated with potassium dichromate and controls, 
      although oxazolone-treated animals showed a significant increase in ear thickness 
      compared to controls. These observations were confirmed using the local lymph 
      node assay (LLNA) where oxazolone proved to be a strong sensitizing agent, and 
      potassium dichromate only resulted in a weak response. When the draining 
      auricular lymph nodes were compared with the inguinal lymph nodes in the LLNA, 
      more pronounced effects were obtained with the auricular lymph nodes. This study 
      indicates that, also in hamsters, the LLNA is a feasible sensitization test 
      system.
FAU - Clottens, F L
AU  - Clottens FL
AD  - Laboratory of Pneumology, K.U. Leuven, Belgium.
FAU - Breyssens, A
AU  - Breyssens A
FAU - De Raeve, H
AU  - De Raeve H
FAU - Demedts, M
AU  - Demedts M
FAU - Nemery, B
AU  - Nemery B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pharmacol Toxicol Methods
JT  - Journal of pharmacological and toxicological methods
JID - 9206091
RN  - 15646-46-5 (Oxazolone)
RN  - T4423S18FM (Potassium Dichromate)
SB  - IM
MH  - Animals
MH  - Cricetinae
MH  - Dermatitis, Contact/*etiology
MH  - Ear, External/*drug effects/immunology
MH  - Edema/chemically induced/immunology
MH  - Female
MH  - Immunologic Tests/*methods
MH  - Lymph Nodes/*drug effects
MH  - Male
MH  - Mesocricetus
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Oxazolone/toxicity
MH  - Potassium Dichromate/toxicity
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 1056-8719(96)00028-7 [pii]
AID - 10.1016/1056-8719(96)00028-7 [doi]
PST - ppublish
SO  - J Pharmacol Toxicol Methods. 1996 Jun;35(3):167-72. doi: 
      10.1016/1056-8719(96)00028-7.