PMID- 8782204
OWN - NLM
STAT- MEDLINE
DCOM- 19961120
LR  - 20171116
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 9
IP  - 6
DP  - 1996 Jun
TI  - Olfactory neuroblastoma and other round cell lesions of the sinonasal region.
PG  - 658-63
AB  - Sixty-nine round cell lesions of the sinonasal region (22 olfactory 
      neuroblastomas [ONBs], 17 malignant lymphomas, nine Ewing's sarcomas [ES], nine 
      rhabdomyosarcomas, three sinonasal undifferentiated carcinomas, five malignant 
      melanomas, and four pituitary adenomas) were studied in an attempt to define the 
      differential diagnostic capabilities of antibody to MIC2 and bcl-2 in 
      paraffin-embedded tissue in the distinction of these lesions. In addition, 
      antibody to p53 was applied in each case to define the incidence of p53 
      positivity among these various tumor types. Each of the ES cases was MIC2 
      positive; each of the other cases was MIC2 negative. Positivity for bcl-2 was 
      confined to two cases, one of them a malignant lymphoma (85% of cells positive) 
      and one an ONB (5% of cells positive). Small numbers of scattered p53-positive 
      cells appeared in the majority of cases studied, without regard for the specific 
      tumor type; only a single case, a malignant lymphoma, showed a majority 
      (approximately 90%) of p53-positive cells. These results indicate that the MIC2 
      antibody is a useful method by which to distinguish ES from a variety of other 
      round cell lesions that may be encountered in the sinonasal region. The practical 
      applications of antibody to bcl-2 and p53 seem to be much more limited; by 
      contrast, neither bcl-2 positive cells nor abundant p53 cells identified by 
      immunohistochemical analysis seemed to be frequent findings in any of the tumor 
      types studied. Although ONBs have been included with the peripheral primitive 
      neuroectodermal tumors for classification purposes, these tumors diverge from the 
      ES/primitive neuroectodermal tumor family in that they do not seem to share 
      either the MIC2 positivity or the t(11;22) chromosomal translocation that typify 
      the ES/primitive neuroectodermal tumor family of lesions. Although bcl-2 
      positivity has been associated with a light microscopic finding of an unfavorable 
      histologic pattern in retroperitoneal neuroblastomas, it does not seem that bcl-2 
      positivity in ONB will select for a clinically distinctive subset of patients.
FAU - Devaney, K
AU  - Devaney K
AD  - Department of Pathology, University of Michigan Hospitals, Ann Arbor 48109-0054, 
      USA.
FAU - Wenig, B M
AU  - Wenig BM
FAU - Abbondanzo, S L
AU  - Abbondanzo SL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (12E7 Antigen)
RN  - 0 (Antigens, CD)
RN  - 0 (CD99 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - 12E7 Antigen
MH  - Adenoma/pathology
MH  - Antigens, CD/analysis
MH  - Carcinoma/pathology
MH  - Carcinoma, Small Cell/*pathology
MH  - Cell Adhesion Molecules/analysis
MH  - Diagnosis, Differential
MH  - Esthesioneuroblastoma, Olfactory/chemistry/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphoma/pathology
MH  - Melanoma/pathology
MH  - *Nasal Cavity
MH  - Nose Neoplasms/chemistry/*pathology
MH  - Paranasal Sinuses/pathology
MH  - Proto-Oncogene Proteins c-bcl-2/analysis
MH  - Rhabdomyosarcoma/pathology
MH  - Sarcoma, Ewing/pathology
MH  - Tumor Suppressor Protein p53/analysis
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
PST - ppublish
SO  - Mod Pathol. 1996 Jun;9(6):658-63.