PMID- 8782871
OWN - NLM
STAT- MEDLINE
DCOM- 19970204
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 719
IP  - 1-2
DP  - 1996 May 6
TI  - Subclasses of vomeronasal receptor neurons: differential expression of G proteins 
      (Gi alpha 2 and G(o alpha)) and segregated projections to the accessory olfactory 
      bulb.
PG  - 117-28
AB  - Differential expression of G proteins (Gi alpha 2 and G(o alpha) and the separate 
      central projections of Gi alpha 2- and G(o alpha)-immunoreactive (ir) vomeronasal 
      receptor neurons were investigated in the mouse and rat using immunocytochemical 
      methods. In the vomeronasal organ (VNO), receptor neurons with their cell bodies 
      located in the middle layer (middle 1/3) of the vomeronasal sensory epithelium 
      express Gi alpha 2. Axons of these Gi alpha 2-ir neurons can be followed from VNO 
      to the anterior part, but not the posterior part, of the nerve-glomerular (N-GL) 
      layer of the accessory olfactory bulb (AOB). Another population of receptor 
      neurons, which are located in the deep layer (basal 1/3) of the vomeronasal 
      sensory epithelium, express G(o alpha), and axons of the G(o alpha)-ir neurons 
      can be traced to the posterior part, but not the anterior part, of the N-GL 
      layers of the AOB. The axons of the two subclasses of receptor neurons are 
      intermingled near the VNO and become segregated as they enter the AOB. Removal of 
      the AOB results in retrograde degeneration of both Gi alpha 2-ir and G(o 
      alpha)-ir receptor neurons in the VNO. These results suggest that at least two 
      subclasses of receptor neurons exist in the VNO: the Gi alpha 2-ir neurons in the 
      middle layer and the G(o alpha)-ir neurons in the deep layer of the VNO. The Gi 
      alpha 2-ir neurons in the middle layer of the VNO project to the anterior part of 
      the AOB, while the G(o alpha)-ir neurons in the deep layer of the VNO project to 
      the posterior half of the AOB. These results are similar to our previous 
      observations in the gray short-tailed opossum, suggesting that the existence of 
      at least two subclasses of receptor neurons in the vomeronasal epithelium with 
      differential projections to the AOB is a conserved feature among mammals.
FAU - Jia, C
AU  - Jia C
AD  - Program in Neural and Behavioral Science, State University of New York Health 
      Science Center at Brooklyn 11203, USA.
FAU - Halpern, M
AU  - Halpern M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Olfactory Marker Protein)
RN  - 0 (Omp protein, mouse)
RN  - 0 (Omp protein, rat)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - Brain Mapping
MH  - Female
MH  - GTP-Binding Proteins/*analysis
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Nerve Tissue Proteins/*analysis
MH  - Olfactory Bulb/*chemistry/cytology
MH  - Olfactory Marker Protein
MH  - Olfactory Pathways/*physiology
MH  - Olfactory Receptor Neurons/*chemistry
MH  - Rats
MH  - Vomeronasal Organ/*chemistry/cytology
EDAT- 1996/05/06 00:00
MHDA- 1996/05/06 00:01
CRDT- 1996/05/06 00:00
PHST- 1996/05/06 00:00 [pubmed]
PHST- 1996/05/06 00:01 [medline]
PHST- 1996/05/06 00:00 [entrez]
AID - 0006-8993(96)00110-2 [pii]
AID - 10.1016/0006-8993(96)00110-2 [doi]
PST - ppublish
SO  - Brain Res. 1996 May 6;719(1-2):117-28. doi: 10.1016/0006-8993(96)00110-2.