PMID- 8784234
OWN - NLM
STAT- MEDLINE
DCOM- 19961010
LR  - 20131121
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 16
IP  - 5
DP  - 1996 Sep
TI  - Neuronal hyperexcitability and reduction of GABAA-receptor expression in the 
      surround of cerebral photothrombosis.
PG  - 906-14
AB  - Changes of neuronal excitability and gamma-aminobutyric acid (GABAA)-receptor 
      expression were studied in the surround of photothrombotic infarcts, which were 
      produced in the sensorimotor cortex of the rat by using the rose bengal 
      technique. In a first series of experiments, multiunit recordings were performed 
      on anesthetized animals 2-3 mm lateral from the lesion. Mean discharge frequency 
      was considerably higher in recordings from lesioned animals (> 100 Hz in the 
      first postlesional week) compared with control animals (mean, 15 Hz). These 
      alterations were already present after 1 day but were most pronounced 3 to 7 days 
      after lesion induction. Thereafter the hyperexcitability declined again, although 
      it remained visible up to 4 months. In a second series of experiments, the 
      GABAA-receptor expression was studied autoradiographically. This revealed a 
      reduction of GABAA receptors in widespread brain areas ipsilateral to the lesion. 
      The reduction was most pronounced in the first days after lesion induction and 
      declined with longer intervals. It is concluded that cortical infarction due to 
      photothrombosis leads to a long-lasting and widespread reduction of 
      GABAA-receptor expression in the surround of the lesion, which is associated with 
      an increased neuronal excitability. Such alterations may be responsible for 
      epileptic seizures that can be observed in some patients after stroke and may 
      contribute to neurologic deficits after stroke.
FAU - Schiene, K
AU  - Schiene K
AD  - Neurologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany.
FAU - Bruehl, C
AU  - Bruehl C
FAU - Zilles, K
AU  - Zilles K
FAU - Qu, M
AU  - Qu M
FAU - Hagemann, G
AU  - Hagemann G
FAU - Kraemer, M
AU  - Kraemer M
FAU - Witte, O W
AU  - Witte OW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Receptors, GABA)
RN  - 1ZPG1ELY14 (Rose Bengal)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Brain/physiopathology
MH  - Cerebrovascular Disorders/physiopathology
MH  - Electrophysiology
MH  - Intracranial Embolism and Thrombosis/etiology/*physiopathology
MH  - Kinetics
MH  - *Light
MH  - Male
MH  - Neurons/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, GABA/*metabolism
MH  - *Rose Bengal
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1097/00004647-199609000-00014 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 1996 Sep;16(5):906-14. doi: 
      10.1097/00004647-199609000-00014.