PMID- 8784865
OWN - NLM
STAT- MEDLINE
DCOM- 19970128
LR  - 20161123
IS  - 0029-5566 (Print)
IS  - 0029-5566 (Linking)
VI  - 35
IP  - 4
DP  - 1996 Aug
TI  - Follow-up of osteomyelitis of infants with systemic serum parameters and bone 
      scintigraphy.
PG  - 116-21
AB  - AIM: To prevent orthopedic sequelae in acute hematogenous pyogenic osteomyelitis 
      (AHPO) of infants early diagnosis, recognition of recurrence and effective 
      therapy is needed. This retrospective study of 47 infants with bacteriologically 
      confirmed AHPO concerned with an analysis of the diagnostic value of systemic 
      serum parameters compared to bone scintigraphy (BSC). METHODS: AHPO was 
      characterized initially and during the course of disease by clinical findings, 
      C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), total and 
      differential white blood cell (WBC) count, BSC, and plain radiography. RESULTS: 
      CRP was the most effective serum parameter for follow-up of disease. The first 
      sign of BSC to signal adequate response to antibiotic treatment was the decrease 
      or normalization of hyperperfusion. Escape from therapy or poor prognosis, even 
      when the serum parameters were normalized, was signaled by the recurrence of 
      focal hyperperfusion and the persistent or increasing local uptake ratios on the 
      3-h-image over 6 weeks during a course of antibiotic treatment. CONCLUSION: 
      Antibiotic treatment masks the clinical presentation, and the radiographic 
      findings, causes non-characteristic laboratory findings, but do not prevent the 
      scintigraphic visualization; BSC and serum parameters used in the right 
      completion are the most successful and efficient modalities for follow-up of 
      AHPO. Maintenance of antibiotic therapy should be done until BSC findings have 
      reverted to normal.
FAU - Aigner, R M
AU  - Aigner RM
AD  - Department of Radiology, University Hospital, Graz, Austria.
FAU - Fueger, G F
AU  - Fueger GF
FAU - Vejda, M
AU  - Vejda M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Nuklearmedizin
JT  - Nuklearmedizin. Nuclear medicine
JID - 7609387
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Bacterial Infections/*epidemiology
MH  - Biomarkers/blood
MH  - Blood Sedimentation
MH  - Bone and Bones/*diagnostic imaging
MH  - C-Reactive Protein/analysis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Leukocyte Count
MH  - Male
MH  - Osteomyelitis/*blood/*diagnostic imaging/drug therapy
MH  - Radiography
MH  - Radionuclide Imaging
MH  - Recurrence
MH  - Retrospective Studies
MH  - Time Factors
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
PST - ppublish
SO  - Nuklearmedizin. 1996 Aug;35(4):116-21.