PMID- 8785034
OWN - NLM
STAT- MEDLINE
DCOM- 19960920
LR  - 20181130
IS  - 0253-5068 (Print)
IS  - 0253-5068 (Linking)
VI  - 14
IP  - 2
DP  - 1996
TI  - Mechanisms regulating cytokine release from peritoneal macrophages during 
      continuous ambulatory peritoneal dialysis.
PG  - 179-87
AB  - The proinflammatory cytokines interleukin-1 (IL-1 beta) and tumor necrosis 
      factor-alpha (TNF alpha) are key mediators of the body's response to infection. 
      Peritoneal macrophages from continuous ambulatory peritoneal dialysis (CAPD) 
      patients isolated during peritonitis have an increased capacity to secrete IL-1 
      beta and TNF alpha. This peritoneal macrophage activation for IL-1 beta and TNF 
      alpha release is a two-stage process. In contrast, peritonitis macrophages and 
      infection-free macrophages stimulated in vitro with bacteria generate a decreased 
      amount of the anti-inflammatory prostanoids. Exogenous and endogenous 
      prostaglandin E2 (PGE2) was found to inhibit the release of TNF alpha rather than 
      IL-1 beta from peritoneal macrophages, indicating that the synthesis and 
      secretion of these cytokines is distinctly regulated by PGE2. In addition to 
      macrophage products, acting in an autocrine fashion cytokine production and 
      release may be regulated by secretory products of other cells in the peritoneal 
      cavity including lymphocytes and mesothelial cells, which have the capability to 
      produce various mediators. No evidence was found that the NO system is an 
      important part of the antimicrobial arsenal of peritoneal macrophages.
FAU - Fieren, M W
AU  - Fieren MW
AD  - Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus 
      University Rotterdam, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Blood Purif
JT  - Blood purification
JID - 8402040
RN  - 0 (Interleukin-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Dinoprostone/physiology
MH  - Interleukin-1/*metabolism
MH  - Macrophages, Peritoneal/*metabolism
MH  - Mice
MH  - Models, Biological
MH  - Nitric Oxide/metabolism
MH  - *Peritoneal Dialysis, Continuous Ambulatory
MH  - Peritonitis/physiopathology
MH  - Rats
MH  - Tumor Necrosis Factor-alpha/*metabolism
RF  - 60
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1159/000170261 [doi]
PST - ppublish
SO  - Blood Purif. 1996;14(2):179-87. doi: 10.1159/000170261.