PMID- 8786385
OWN - NLM
STAT- MEDLINE
DCOM- 19960920
LR  - 20190512
IS  - 0022-3069 (Print)
IS  - 1554-6578 (Electronic)
IS  - 0022-3069 (Linking)
VI  - 55
IP  - 3
DP  - 1996 Mar
TI  - Correlation of astrocytic S100 beta expression with dystrophic neurites in 
      amyloid plaques of Alzheimer's disease.
PG  - 273-9
AB  - The neurite extension factor S100 beta is overexpressed by activated astrocytes 
      associated with amyloid-containing plaques in Alzheimer's disease, and has been 
      implicated in dystrophic neurite formation in these plaques. This predicts (a) 
      that the appearance of S100beta- immunoreactive (S100beta+) astrocytes precedes 
      that of dystrophic neurites in diffuse amyloid deposits and (b) that the number 
      of these astrocytes correlates with the degree of dystrophic neurite 
      proliferation in neuritic plaques. As a test of the first prediction, we 
      determined the number of S100beta+ astrocytes associated with different plaque 
      types: diffuse non-neuritic, diffuse neuritic, dense-core neuritic, and 
      dense-core non-neuritic. Diffuse non-neuritic plaques had small numbers of 
      associated S100beta+ astrocytes (1.3 +/- 0.1 S100beta astrocytes per plaque [mean 
      +/- SEM]; 80% of plaques had one or more). These astrocytes were most abundant in 
      diffuse neuritic plaques (4.2 +/- 0.2; 100%), were somewhat less numerous in 
      dense-core neuritic plaques (1.6 +/- 0.2; 90%), and were only rarely associated 
      with dense-core non-neuritic plaques (0.15 +/- 0.05; 12%). As a test of the 
      second prediction, we correlated the number of S100beta+ astrocytes per plaque 
      with the area of beta-amyloid precursor protein (beta-APP) immunoreactivity per 
      plaque (an index of the size of the plaques' dystrophic neurite shells) and found 
      a significant positive correlation (r = 0.74, p < 0.001). This correlation was 
      also evident at the tissue level: the numbers of S100beta+ astrocytes per 
      plaque-rich field correlated with the total area beta-APP immunoreactivity in 
      these fields (r = 0.66, p < 0.05). These correlations support the idea that 
      astrocytic activation and S100 beta overexpression are involved in the induction 
      and maintenance of dystrophic neurites in amyloid deposits, and support the 
      concept of a glial cytokine-mediated cascade underlying the progression of 
      neuropathological changes in Alzheimer's disease.
FAU - Mrak, R E
AU  - Mrak RE
AD  - Department of Veterans' Affairs Medical Center, Little Rock, Arkansas, USA.
FAU - Sheng, J G
AU  - Sheng JG
FAU - Griffin, W S
AU  - Griffin WS
LA  - eng
GR  - P01 AG012411/AG/NIA NIH HHS/United States
GR  - AG10208/AG/NIA NIH HHS/United States
GR  - AG12411/AG/NIA NIH HHS/United States
GR  - AG27414/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Amyloid beta-Protein Precursor)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*pathology
MH  - Amyloid beta-Protein Precursor/genetics/*metabolism
MH  - Astrocytes/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Middle Aged
MH  - Neurites/*pathology
PMC - PMC3833601
MID - NIHMS524648
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
PMCR- 2013/11/19
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
PHST- 2013/11/19 00:00 [pmc-release]
AID - 10.1097/00005072-199603000-00002 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 1996 Mar;55(3):273-9. doi: 
      10.1097/00005072-199603000-00002.