PMID- 8790307 OWN - NLM STAT- MEDLINE DCOM- 19961010 LR - 20190702 IS - 0038-4348 (Print) IS - 0038-4348 (Linking) VI - 89 IP - 9 DP - 1996 Sep TI - Allogeneic bone marrow transplantation. PG - 857-68 AB - Allogeneic bone marrow transplantation (BMT) after high-dose, marrow-ablative chemoradiotherapy has been established as the treatment of choice for various hematologic, neoplastic, and congenital disorders. The most common type of marrow graft is an allogeneic one from a sibling donor who has compatible human leukocyte antigen (HLA). Only 30% of patients requiring allogeneic BMT have an HLA-compatible sibling donor. Over the past few years, marrows from unrelated HLA-compatible donors have been used with increasing frequency and promising outcome in certain hematologic malignancies. Despite the morbidity and mortality associated with this treatment modality, allogeneic BMT may provide a 20% to 90% chance of long-term, disease-free survival to patients with a wide variety of neoplastic and abnormal marrow disorders. FAU - Tabbara, I A AU - Tabbara IA AD - Bone Marrow Transplant Program, George Washington University School of Medicine, Washington, DC 20037, USA. LA - eng PT - Journal Article PT - Review PL - United States TA - South Med J JT - Southern medical journal JID - 0404522 RN - 0 (HLA Antigens) SB - IM MH - Bone Marrow/drug effects/radiation effects MH - Bone Marrow Diseases/therapy MH - Bone Marrow Purging/methods MH - Bone Marrow Transplantation/adverse effects/*methods MH - Disease-Free Survival MH - HLA Antigens/genetics MH - Hematologic Diseases/therapy MH - Histocompatibility MH - Humans MH - Neoplasms/therapy MH - Transplantation, Homologous MH - Treatment Outcome RF - 113 EDAT- 1996/09/01 00:00 MHDA- 1996/09/01 00:01 CRDT- 1996/09/01 00:00 PHST- 1996/09/01 00:00 [pubmed] PHST- 1996/09/01 00:01 [medline] PHST- 1996/09/01 00:00 [entrez] AID - 10.1097/00007611-199609000-00003 [doi] PST - ppublish SO - South Med J. 1996 Sep;89(9):857-68. doi: 10.1097/00007611-199609000-00003.