PMID- 8790425
OWN - NLM
STAT- MEDLINE
DCOM- 19961024
LR  - 20191210
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 93
IP  - 18
DP  - 1996 Sep 3
TI  - Identification of potential target genes for the neuron-restrictive silencer 
      factor.
PG  - 9881-6
AB  - The neuron-restrictive silencer factor (NRSF) represses transcription of several 
      neuronal genes in nonneuronal cells by binding to a 21-bp element called the 
      neuron-restrictive silencer element (NRSE). We have performed data base searches 
      with a composite NRSE to identify additional candidate NRSF target genes. 
      Twenty-two more genes, 17 of which are expressed mainly in neurons, were found to 
      contain NRSE-like sequences. Many of these putative NRSEs bound NRSF in vitro and 
      repressed transcription in vivo. Most of the neuronal genes identified contribute 
      to the basic structural or functional properties of neurons. However, two 
      neuronal transcription factor genes contain NRSEs, suggesting that NRSF may 
      repress neuronal differentiation both directly and indirectly. Functional NRSEs 
      were also found in several nonneuronal genes, implying that NRSF may play a 
      broader role than originally anticipated.
FAU - Schoenherr, C J
AU  - Schoenherr CJ
AD  - Division of Biology 216-76, California Institute of Technology, Pasadena 91125, 
      USA.
FAU - Paquette, A J
AU  - Paquette AJ
FAU - Anderson, D J
AU  - Anderson DJ
LA  - eng
SI  - GENBANK/UNKNOWN
GR  - NS23476/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (RE1-silencing transcription factor)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 1.14.17.1 (Dopamine beta-Hydroxylase)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cattle
MH  - DNA-Binding Proteins/*metabolism
MH  - Databases, Factual
MH  - Dopamine beta-Hydroxylase/genetics
MH  - Ducks
MH  - Electrophoresis, Polyacrylamide Gel
MH  - *Gene Expression Regulation
MH  - Guinea Pigs
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Rats
MH  - *Regulatory Sequences, Nucleic Acid
MH  - Repressor Proteins/*genetics
MH  - Sequence Homology, Nucleic Acid
MH  - Sheep
MH  - Sodium-Potassium-Exchanging ATPase/genetics
MH  - Transcription Factors/*metabolism
MH  - Zinc Fingers/*genetics
PMC - PMC38523
EDAT- 1996/09/03 00:00
MHDA- 1996/09/03 00:01
PMCR- 1997/03/03
CRDT- 1996/09/03 00:00
PHST- 1996/09/03 00:00 [pubmed]
PHST- 1996/09/03 00:01 [medline]
PHST- 1996/09/03 00:00 [entrez]
PHST- 1997/03/03 00:00 [pmc-release]
AID - 10.1073/pnas.93.18.9881 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9881-6. doi: 10.1073/pnas.93.18.9881.