PMID- 8790673
OWN - NLM
STAT- MEDLINE
DCOM- 19961001
LR  - 20191024
IS  - 0272-4936 (Print)
IS  - 0272-4936 (Linking)
VI  - 16
IP  - 2
DP  - 1996 Jun
TI  - Haemophilus influenzae type b disease in the western region of The Gambia: 
      background surveillance for a vaccine efficacy trial.
PG  - 103-11
AB  - In preparation for a field trial of an Haemophilus influenzae type b conjugate 
      vaccine in the Western Region of The Gambia, a 3-year prospective study was 
      undertaken to determine the incidence of Hib disease and the vaccination status 
      of affected children. One hundred and eighty-two children with invasive Hib 
      disease were found; 141 (77%) had meningitis, 31 (17%) pneumonia and 10 (6%) 
      other forms of invasive disease. The estimated annual incidence rates for all 
      invasive Hib diseases were 274 and 73 per 100,000 in children aged < 1 and < 5 
      years, respectively. For meningitis, the rate was 222 per 100,000 per year in 
      children aged < 1 year. Children with meningitis were significantly younger than 
      those with pneumonia (median age 7 months, interquartile range [IQR] 5-9, vs 12 
      months, IQR 6-15 (P = 0.002)) and younger than those with other forms of Hib 
      disease. Of 142 children for whom vaccination status was known, 18 had received 
      no DPT, 36 had received one, 40 had received two and 48 had received three doses. 
      This study confirmed the high incidence of systemic Hib disease among Gambian 
      children and the need to vaccinate at an early age. It provided the background 
      epidemiological data required for the successful planning of an Hib vaccine trial 
      which is now in progress.
FAU - Adegbola, R A
AU  - Adegbola RA
AD  - Medical Research Council Laboratory, Fajara.
FAU - Mulholland, E K
AU  - Mulholland EK
FAU - Falade, A G
AU  - Falade AG
FAU - Secka, O
AU  - Secka O
FAU - Sarge-Njai, R
AU  - Sarge-Njai R
FAU - Corrah, T
AU  - Corrah T
FAU - Palmer, A
AU  - Palmer A
FAU - Schneider, G
AU  - Schneider G
FAU - Greenwood, B M
AU  - Greenwood BM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann Trop Paediatr
JT  - Annals of tropical paediatrics
JID - 8210625
RN  - 0 (Diphtheria-Tetanus-Pertussis Vaccine)
RN  - 0 (Haemophilus Vaccines)
RN  - 0 (Vaccines, Conjugate)
SB  - IM
MH  - Age Distribution
MH  - Child, Preschool
MH  - Data Interpretation, Statistical
MH  - Diphtheria-Tetanus-Pertussis Vaccine
MH  - Gambia/epidemiology
MH  - Haemophilus Infections/*epidemiology/prevention & control
MH  - Haemophilus Vaccines/*therapeutic use
MH  - *Haemophilus influenzae/isolation & purification
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Meningitis, Bacterial/epidemiology/microbiology
MH  - Pneumonia, Bacterial/epidemiology/microbiology
MH  - *Population Surveillance
MH  - Prospective Studies
MH  - Vaccines, Conjugate
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 10.1080/02724936.1996.11747812 [doi]
PST - ppublish
SO  - Ann Trop Paediatr. 1996 Jun;16(2):103-11. doi: 10.1080/02724936.1996.11747812.