PMID- 8792074
OWN - NLM
STAT- MEDLINE
DCOM- 19961101
LR  - 20071114
IS  - 0272-2712 (Print)
IS  - 0272-2712 (Linking)
VI  - 16
IP  - 2
DP  - 1996 Jun
TI  - Hepatocellular injury in hepatitis B and C virus infections.
PG  - 307-24
AB  - Most of the liver cell injury in hepatitis B and C infections is likely to be 
      immune-mediated. Variation in the pathogenesis of these infections likely is 
      contributed by a variety of host and virus factors. Host factors include the 
      human leukocyte antigen (HLA) haplotype as well as the ability of the host to 
      both recognize antigen on virus-infected cells and to receive the appropriate 
      co-stimulatory signals in a timely fashion during infection. Virus factors 
      include the genetic variation, direct cytopathic effects, and the alteration of 
      infected hepatocytes to cytotoxic cytokines. The lack of suitable tissue culture 
      systems and animal models limits the ability to understand the pathogenesis fully 
      but provides challenges for their future development so that the basis for liver 
      cell damage can be elucidated and approaches for therapeutic intervention can be 
      achieved.
FAU - Feitelson, M A
AU  - Feitelson MA
AD  - Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 
      Philadelphia, Pennsylvania, USA.
LA  - eng
GR  - CA48656/CA/NCI NIH HHS/United States
GR  - CA66971/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Clin Lab Med
JT  - Clinics in laboratory medicine
JID - 8100174
RN  - 0 (Hepatitis Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Animals
MH  - Hepatitis Antigens/immunology
MH  - Hepatitis B/immunology/*pathology
MH  - Hepatitis C/immunology/*pathology
MH  - Histocompatibility Antigens Class I
MH  - Humans
MH  - Interferons
MH  - Liver/immunology/*pathology
RF  - 110
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
PST - ppublish
SO  - Clin Lab Med. 1996 Jun;16(2):307-24.