PMID- 8793207
OWN - NLM
STAT- MEDLINE
DCOM- 19961209
LR  - 20191101
IS  - 0967-3849 (Print)
IS  - 0967-3849 (Linking)
VI  - 4
IP  - 3
DP  - 1996 Apr
TI  - Zoo-FISH delineates conserved chromosomal segments in horse and man.
PG  - 218-25
AB  - Human chromosome specific libraries (CSLs) were individually applied to equine 
      metaphase chromosomes using the fluorescence in situ hybridization (FISH) 
      technique. All CSLs, except Y, showed painting signals on one or several horse 
      chromosomes. In total 43 conserved chromosomal segments were painted. Homoeology 
      could not, however, be detected for some segments of the equine genome. This is 
      most likely related to the very weak signals displayed by some libraries, rather 
      than to the absence of similarity with the human genome. In spite of divergence 
      from the human genome, dated 70-80 million years ago, a fairly high degree of 
      synteny conservation was observed. In seven cases, whole chromosome synteny was 
      detected between the two species. The comparative painting results agreed 
      completely with the limited gene mapping data available in horses, and also 
      enabled us provisionally to assign one linkage group (U2) and one syntenic group 
      (NP, MPI, IDH2) to specific equine chromosomes. Chromosomal assignments of three 
      other syntenic groups are also proposed. The findings of this study will be of 
      significant use in the expansion of the hitherto poorly developed equine gene 
      map.
FAU - Raudsepp, T
AU  - Raudsepp T
AD  - Department of Animal Breeding and Genetics, Swedish University of Agricultural 
      Sciences, Uppsala, Sweden.
FAU - Fronicke, L
AU  - Fronicke L
FAU - Scherthan, H
AU  - Scherthan H
FAU - Gustavsson, I
AU  - Gustavsson I
FAU - Chowdhary, B P
AU  - Chowdhary BP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Chromosome Res
JT  - Chromosome research : an international journal on the molecular, supramolecular 
      and evolutionary aspects of chromosome biology
JID - 9313452
SB  - IM
CIN - Chromosome Res. 1998 Jun;6(4):333-5. PMID: 9688525
MH  - Animals
MH  - *Chromosome Mapping/veterinary
MH  - Chromosomes/ultrastructure
MH  - Chromosomes, Human/ultrastructure
MH  - *Evolution, Molecular
MH  - Hominidae/*genetics
MH  - Horses/*genetics
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Phylogeny
MH  - Species Specificity
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1007/BF02254963 [doi]
PST - ppublish
SO  - Chromosome Res. 1996 Apr;4(3):218-25. doi: 10.1007/BF02254963.