PMID- 8793452
OWN - NLM
STAT- MEDLINE
DCOM- 19961206
LR  - 20190821
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 9
IP  - 5
DP  - 1996 May
TI  - Serum house dust mite antibodies: predictor of increased bronchial responsiveness 
      in adults of a community.
PG  - 919-25
AB  - The purpose of this study was to determine whether the presence of serum specific 
      immunoglobulin E (IgE) antibodies was associated with increased bronchial 
      responsiveness in adults. We studied cross-sectionally a random community sample 
      of 18-73 year old adults, of whom 83% (n = 489) performed bronchial 
      responsiveness testing as well as serum measurements of five specific IgE 
      antibodies. In the crude data, 39% of those with house dust mite antibodies (n = 
      18) had a bronchial responsiveness < or = 32 g.L-1 methacholine compared with 19% 
      in subjects without any of the five specific IgE antibodies (n = 453). The 
      corresponding percentages for subjects with timothy antibodies (n = 16) was 25%, 
      birch antibodies (n = 13) 23%, cat antibodies (n = 10) 40% and mould antibodies 
      (n = 2) 50%. When assessing the multivariate relationship between the presence of 
      one specific IgE antibody and degree of bronchial responsiveness we used a 
      semi-proportional hazards model with the response as a 20% fall in forced 
      expiratory volume in one second (FEV1) from pretest value. Covariates included in 
      the model were: gender, age, pretest FEV1, smoking habits, pack-years, season and 
      other specific IgE antibodies than that examined. The presence of house dust mite 
      antibodies was a significant predictor (p < 0.01) of increased bronchial 
      responsiveness in never- and ex-smokers. Indoor allergic sensitization (house 
      dust mite, cat and mould) was a significant predictor of increased bronchial 
      responsiveness, while outdoor allergic sensitization (timothy and birch) was not. 
      Excluding subjects with obstructive lung disease (n = 39) or including the 
      covariate log total serum IgE as a potential confounder yielded the same result. 
      Thus, in this community, indoor allergic sensitization rather than allergic 
      sensitization per se was related to increased bronchial responsiveness after 
      adjusting for other relevant covariates.
FAU - Omenaas, E
AU  - Omenaas E
AD  - Dept of Thoracic Medicine, University of Bergen, Norway.
FAU - Bakke, P
AU  - Bakke P
FAU - Eide, G E
AU  - Eide GE
FAU - Elsayed, S
AU  - Elsayed S
FAU - Gulsvik, A
AU  - Gulsvik A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Dust)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Animals
MH  - Antibodies, Anti-Idiotypic/*analysis
MH  - *Bronchial Hyperreactivity/immunology/physiopathology
MH  - Bronchial Provocation Tests
MH  - Cats
MH  - Cross-Sectional Studies
MH  - Data Collection
MH  - Dust/*adverse effects
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Male
MH  - Middle Aged
MH  - Norway
MH  - Proportional Hazards Models
MH  - Random Allocation
MH  - Respiratory Function Tests
MH  - Risk Factors
MH  - Sampling Studies
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1183/09031936.96.09050919 [doi]
PST - ppublish
SO  - Eur Respir J. 1996 May;9(5):919-25. doi: 10.1183/09031936.96.09050919.