PMID- 8793636
OWN - NLM
STAT- MEDLINE
DCOM- 19961204
LR  - 20191210
IS  - 0937-9827 (Print)
IS  - 0937-9827 (Linking)
VI  - 108
IP  - 6
DP  - 1996
TI  - Concentrations of delta 9-tetrahydrocannabinol, cocaine and 6-monoacetylmorphine 
      in hair of drug abusers.
PG  - 294-9
AB  - Hair samples taken from 850 individuals with presumed drug abuse were tested 
      simultaneously for delta 9-tetrahydrocannabinol (THC), cocaine, heroin, the 
      primary heroin metabolite 6-monoacetylmorphine (6-MAM) and morphine. The drugs 
      were extracted with methanol under sonication. Compared to other extraction 
      procedures this solvent extraction technique provides high extraction yields and 
      less experimental effort. The analyses were carried out using gas 
      chromatography-mass spectrometry (GCMS) in selected ion monitoring (SIM) mode. 
      This procedure allows the simultaneous detection of amphetamine, 
      methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA) and 
      methylenedioxylamphetamine (MDE). THC was found in 104 (12.2%), cocaine in 230 
      (27%) and 6-MAM in 141 (16.6%) samples. In addition to 6-MAM, morphine was 
      detected in 87 (10.2%) and heroin in 38 samples (4.5%). The concentrations found 
      were in a range 0.009-16.7 ng/mg for THC, 0.037-129.68 ng/mg for cocaine, 
      0.028-79.82 ng/mg for 6-MAM, 0.045-53.14 ng/mg for heroin and 0.011-7.800 ng/mg 
      for morphine. The statistical distribution of the drug concentrations compared 
      with the self-reported consumption behaviour of the users may possibly lead to a 
      better understanding of the relationship between drug dosage and corresponding 
      concentrations in hair.
FAU - Kauert, G
AU  - Kauert G
AD  - Zentrum der Rechtsmedizin, Universitat Frankfurt, Germany.
FAU - Rohrich, J
AU  - Rohrich J
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Int J Legal Med
JT  - International journal of legal medicine
JID - 9101456
RN  - 0 (Designer Drugs)
RN  - 0 (Illicit Drugs)
RN  - 0 (Morphine Derivatives)
RN  - 0 (Psychotropic Drugs)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 7J8897W37S (Dronabinol)
RN  - CK833KGX7E (Amphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - M5E47P1ZCH (6-O-monoacetylmorphine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/analysis
MH  - Accidents, Traffic/legislation & jurisprudence
MH  - Amphetamine/analysis
MH  - Cocaine/*analysis
MH  - Crime/legislation & jurisprudence
MH  - Designer Drugs/analysis
MH  - Dronabinol/*analysis
MH  - Expert Testimony/legislation & jurisprudence
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hair/*chemistry
MH  - Heroin Dependence/*diagnosis
MH  - Humans
MH  - Illicit Drugs/*analysis
MH  - Marijuana Abuse/*diagnosis
MH  - Morphine Derivatives/*analysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analysis
MH  - Opioid-Related Disorders/*diagnosis
MH  - Psychotropic Drugs/*analysis
MH  - Sensitivity and Specificity
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1007/BF02432123 [doi]
PST - ppublish
SO  - Int J Legal Med. 1996;108(6):294-9. doi: 10.1007/BF02432123.