PMID- 8793667
OWN - NLM
STAT- MEDLINE
DCOM- 19961119
LR  - 20220410
IS  - 0303-6987 (Print)
IS  - 0303-6987 (Linking)
VI  - 23
IP  - 3
DP  - 1996 Jun
TI  - An objective measurement of the anchoring strength of anagen hair in an adult 
      with the loose anagen hair syndrome.
PG  - 288-92
AB  - A 21-year-old male presented with the life-long symptom of slowly growing, easily 
      extractable hair lacking sheath remnants. The distribution and density of all his 
      hair regions appeared normal and there was no alopecia. A hair-pull test was 
      painless and resulted in all hairs being removed, all in keeping with a diagnosis 
      of loose anagen hair syndrome (LAHS). The trichogram was normal. Electronically 
      measured epilation revealed values which were significantly lower than controls. 
      His hair follicles were remarkable for this syndrome in that they looked 
      perfectly normal with light microscopy; however, the segment of the follicle with 
      the keratogenous zone was significantly shorter than normal. It is postulated 
      that a subtle intercellular defect must reside in the line of shear proximal to 
      the level of cuticular differentiation to account for the weak anchoring of the 
      root in the follicle. A consequence of a genetic error probably causes both the 
      weak anchoring and the slow hair growth.
FAU - Chapman, D M
AU  - Chapman DM
AD  - Department of Anatomy and Neurobiology, Dalhousie University, Nova Scotia, 
      Canada.
FAU - Miller, R A
AU  - Miller RA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
SB  - IM
MH  - Adult
MH  - Female
MH  - Hair Diseases/*pathology
MH  - Hair Follicle/pathology/ultrastructure
MH  - *Hair Removal/instrumentation/methods
MH  - Humans
MH  - Male
MH  - Microscopy, Polarization
MH  - Syndrome
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 10.1111/j.1600-0560.1996.tb01481.x [doi]
PST - ppublish
SO  - J Cutan Pathol. 1996 Jun;23(3):288-92. doi: 10.1111/j.1600-0560.1996.tb01481.x.