PMID- 8793913
OWN - NLM
STAT- MEDLINE
DCOM- 19961203
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 35
IP  - 4
DP  - 1996 Apr
TI  - Protective actions of the 5-HT2A/2C receptor agonist, DOI, on 5-HT1A 
      receptor-mediated inhibition of lordosis behavior.
PG  - 497-501
AB  - Sexually receptive proestrous rats were infused bilaterally into the ventromedial 
      nucleus of the hypothalamus (VMN) with 200 ng of 8-hydroxy-2-(di-n-propylamino) 
      tetralin (8-OH-DPAT), 1000 or 2000 ng of 5-methoxy-3-(di-n-propylamino) chroman 
      (5-MEO-DPAC), or 1000 or 2000 ng of serotonin (5-HT) plus or minus the 5-HT2A/2C 
      agonist, (2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI). DOI protected 
      against the lordosis-inhibiting effects of 5-HT and each of the 5-HT1A agonists. 
      These results substantiate a prior report that 2000 ng DOI could protect against 
      the lordosis-inhibiting action of 200 ng 8-OH-DPAT and demonstrate that such 
      protection is not unique to a single 5-HT1A agonist. Consequently, these results 
      strengthen evidence that functionally significant interactions occur among 5-HT 
      receptors within the VMN.
FAU - Maswood, S
AU  - Maswood S
AD  - Department of Biology, Texas Woman's University, Denton 76204, USA.
FAU - Andrade, M
AU  - Andrade M
FAU - Caldarola-Pastuszka, M
AU  - Caldarola-Pastuszka M
FAU - Uphouse, L
AU  - Uphouse L
LA  - eng
GR  - GM08256/GM/NIGMS NIH HHS/United States
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Amphetamines)
RN  - 0 (Serotonin Receptor Agonists)
RN  - OOM10GW9UE (4-iodo-2,5-dimethoxyphenylisopropylamine)
SB  - IM
MH  - Amphetamines/*pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Female
MH  - *Posture
MH  - Proestrus/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin Receptor Agonists/*pharmacology
MH  - Sexual Behavior, Animal/*drug effects
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 0028390895001956 [pii]
AID - 10.1016/0028-3908(95)00195-6 [doi]
PST - ppublish
SO  - Neuropharmacology. 1996 Apr;35(4):497-501. doi: 10.1016/0028-3908(95)00195-6.