PMID- 8794377
OWN - NLM
STAT- MEDLINE
DCOM- 19961122
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 70
IP  - 10
DP  - 1996 Oct
TI  - The neonatal Fc receptor is not required for mucosal infection by mouse mammary 
      tumor virus.
PG  - 7250-4
AB  - The milk-borne mouse mammary tumor virus (MMTV) infects newborn mice via the 
      intestine. Infection is initially restricted to Peyer's patches and later spreads 
      to the epithelial cells of the mammary gland. The receptor that mediates uptake 
      and transport of MMTV across the intestinal barrier has not yet been identified, 
      The neonatal Fc receptor (nFcR), which is expressed by enterocytes during the 
      first two weeks of life, is downregulated at weaning, and its disappearance 
      correlates with the onset of intestinal resistance to MMTV. To test whether the 
      nFcR mediates transport and allows infection, we foster nursed on infected MMTV 
      mothers beta2 microglobulin-deficient (beta2m-deficient) newborn mice that are 
      unable to express the nFcR at the surface of their enterocytes. Exposure of 
      beta2m-deficient mice to milk-borne virus resulted in the deletion of peripheral 
      blood T cells reactive to the superantigen encoded by MMTV. Since 
      beta2m-deficient newborn mice are susceptible to MMTV infection despite the lack 
      of the nFcR, we conclude that the nFcR is not required for MMTV transport.
FAU - Velin, D
AU  - Velin D
AD  - Swiss Institute for Experimental Cancer Research, University of Lausanne, 
      Epalinges, Switzerland.
FAU - Acha-Orbea, H
AU  - Acha-Orbea H
FAU - Kraehenbuhl, J P
AU  - Kraehenbuhl JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Receptors, Fc)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Intestinal Mucosa/*immunology/virology
MH  - *Mammary Tumor Virus, Mouse
MH  - Mice
MH  - Receptors, Fc/*immunology
MH  - Retroviridae Infections/*immunology
MH  - T-Lymphocytes/*immunology
MH  - Tumor Virus Infections/*immunology
PMC - PMC190783
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
PMCR- 1996/10/01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
PHST- 1996/10/01 00:00 [pmc-release]
AID - 10.1128/JVI.70.10.7250-7254.1996 [doi]
PST - ppublish
SO  - J Virol. 1996 Oct;70(10):7250-4. doi: 10.1128/JVI.70.10.7250-7254.1996.