PMID- 8795665
OWN - NLM
STAT- MEDLINE
DCOM- 19961010
LR  - 20190503
IS  - 0040-6376 (Print)
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
VI  - 51
IP  - 8
DP  - 1996 Aug
TI  - Relationship of serum IgE concentration to level and rate of decline of pulmonary 
      function: the Normative Aging Study.
PG  - 787-92
AB  - BACKGROUND: Previous reports on the relationship between serum immunoglobulin E 
      (IgE) concentration and the level and rate of decline of pulmonary function in 
      the general population have produced conflicting results. The relationship 
      between total serum IgE concentration and pulmonary function was therefore 
      examined in 1078 men aged 41-86 years followed in the Normative Aging Study. 
      METHODS: The serum IgE concentration determined at the start of the three year 
      follow up period was examined in relation to both the level and longitudinal rate 
      of decline of forced expiratory volume in one second (FEV1), forced vital 
      capacity (FVC), and FEV1/FVC. RESULTS: In a cross sectional analysis restricted 
      to subjects who had ever smoked cigarettes, multiple linear regression models 
      indicated an inverse association between total serum IgE concentration and both 
      FEV1 (beta = -0.090 1/log10 IU/ml; SE = 0.030; p < 0.005) and FVC (beta = -0.110 
      1/log10 IU/ml; SE = 0.034; p < 0.005) but not FEV1/FVC, after adjustment for age 
      and height. This relationship persisted when individuals with diagnosed asthma or 
      methacholine hyperresponsiveness were excluded. In subjects who had never smoked 
      cigarettes the total serum IgE concentration was unrelated to spirometric 
      indices. No association was observed in smokers or non-smokers between the serum 
      IgE concentration measured at the beginning of the period of follow up and the 
      decline in FEV1, FVC, or FEV1/FVC. CONCLUSION: Increased levels of serum IgE 
      measured at the beginning of the follow up period are associated with lower 
      levels of pulmonary function but are not predictive of an accelerated rate in the 
      decline of pulmonary function among middle aged and older men.
FAU - Shadick, N A
AU  - Shadick NA
AD  - Department of Veterans Affairs Outpatient Clinic, Boston, Massachusetts, USA.
FAU - Sparrow, D
AU  - Sparrow D
FAU - O'Connor, G T
AU  - O'Connor GT
FAU - DeMolles, D
AU  - DeMolles D
FAU - Weiss, S T
AU  - Weiss ST
LA  - eng
GR  - HL-19170/HL/NHLBI NIH HHS/United States
GR  - HL-34645/HL/NHLBI NIH HHS/United States
GR  - HL-45089/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/blood/*physiology
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Lung/*physiology
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Respiratory Function Tests
MH  - Smoking/physiopathology
PMC - PMC472538
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
PMCR- 1999/08/01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
PHST- 1999/08/01 00:00 [pmc-release]
AID - 10.1136/thx.51.8.787 [doi]
PST - ppublish
SO  - Thorax. 1996 Aug;51(8):787-92. doi: 10.1136/thx.51.8.787.