PMID- 8795688
OWN - NLM
STAT- MEDLINE
DCOM- 19961018
LR  - 20190826
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 20
IP  - 7
DP  - 1996 Jul
TI  - Study of clonality in myelodysplastic syndromes: detection of trisomy 8 in bone 
      marrow cell smears by fluorescence in situ hybridization.
PG  - 551-7
AB  - The lineage involvement in myelodysplastic syndromes (MDS) is still unclear. To 
      determine the clonality and the evolution of the disorder, a retrospective study 
      on bone marrow smears from seven MDS patients with trisomy 8 was performed using 
      fluorescence in situ hybridization (FISH). We observed that the trisomy of 
      chromosome 8 was selectively expressed in the myeloid-derived cells. No mature 
      lymphocytes or plasma cells expressed three signals. Our studies demonstrate here 
      the value of FISH for identifying the affected cell lineage. Furthermore, the 
      easy quantification of the abnormal cells can help in assessing the progression 
      of the disease.
FAU - Abruzzese, E
AU  - Abruzzese E
AD  - Department of Pediatrics, Bowman Gray School of Medicine, Wake Forest University, 
      Winston-Salem, NC 27157-1076, USA. eabruzze@bgsm.edu
FAU - Buss, D
AU  - Buss D
FAU - Rainer, R
AU  - Rainer R
FAU - Rao, P N
AU  - Rao PN
FAU - Pettenati, M J
AU  - Pettenati MJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
CIN - Leuk Res. 1996 Jul;20(7):559-62. PMID: 8795689
MH  - Aged
MH  - Bone Marrow/*pathology
MH  - Cell Line
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 8
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia
MH  - Lymphocytes/pathology
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics/pathology
MH  - Retrospective Studies
MH  - Specimen Handling
MH  - *Trisomy
MH  - Tumor Cells, Cultured
MH  - X Chromosome
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 0145-2126(95)00130-1 [pii]
AID - 10.1016/0145-2126(95)00130-1 [doi]
PST - ppublish
SO  - Leuk Res. 1996 Jul;20(7):551-7. doi: 10.1016/0145-2126(95)00130-1.