PMID- 8797089
OWN - NLM
STAT- MEDLINE
DCOM- 19970401
LR  - 20190512
IS  - 0021-924X (Print)
IS  - 0021-924X (Linking)
VI  - 119
IP  - 5
DP  - 1996 May
TI  - Isolation and characterization of the human inter-alpha-trypsin inhibitor family 
      heavy chain-related protein (IHRP) gene (ITIHL1).
PG  - 898-905
AB  - Inter-alpha-trypsin inhibitor (ITI) family heavy chain-related protein (IHRP) is 
      a novel human glycoprotein that shows significant homology in amino acid sequence 
      to proteins of the ITI family heavy chains from human plasma. Three overlapping 
      clones that encode the human inter-alpha-trypsin inhibitor family heavy 
      chain-related protein (IHRP) gene (ITIHL1) were isolated and characterized. The 
      IHRP gene spans 15 kb and is composed of 24 exons from 27 to 207 bp in size with 
      consensus splice sites. The gene codes for the precursor of IHRP, which is 
      similar to inter-alpha-trypsin inhibitor (ITI) family heavy chains. Two major 
      transcription initiation sites were identified in the 5'-flanking region. They 
      contain putative promoter elements, but no typical TATA box. Some exons of this 
      gene showed significant similarities to those of the ITI-H1 gene in nucleotide 
      length and in intron phasing. The tissue-specific transcription of this gene may 
      be due to the presence of binding sites for the hepatocyte nuclear factors LF-A1, 
      HNF-5, NF-IL6, and C/EBP. This gene was found to be localized very close to 
      another unknown gene related to EST (GenBank accession #: R54643, R50663, R50563, 
      H27139, and R54913).
FAU - Saguchi, K
AU  - Saguchi K
AD  - Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa 
      University, Tokyo.
FAU - Tobe, T
AU  - Tobe T
FAU - Hashimoto, K
AU  - Hashimoto K
FAU - Nagasaki, Y
AU  - Nagasaki Y
FAU - Oda, E
AU  - Oda E
FAU - Nakano, Y
AU  - Nakano Y
FAU - Miura, N H
AU  - Miura NH
FAU - Tomita, M
AU  - Tomita M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Biochem
JT  - Journal of biochemistry
JID - 0376600
RN  - 0 (Blood Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Glycoproteins)
RN  - 0 (ITIH4 protein, human)
RN  - 0 (Protein Precursors)
RN  - 0 (Proteinase Inhibitory Proteins, Secretory)
SB  - IM
MH  - Base Sequence
MH  - Blood Proteins/*genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Exons
MH  - Glycoproteins/*genetics
MH  - Humans
MH  - In Situ Hybridization
MH  - Introns
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic
MH  - Protein Precursors/genetics
MH  - Proteinase Inhibitory Proteins, Secretory
MH  - Transcription, Genetic
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.jbchem.a021327 [doi]
PST - ppublish
SO  - J Biochem. 1996 May;119(5):898-905. doi: 10.1093/oxfordjournals.jbchem.a021327.