PMID- 8797696
OWN - NLM
STAT- MEDLINE
DCOM- 19961029
LR  - 20191024
IS  - 1077-9450 (Print)
IS  - 1077-9450 (Linking)
VI  - 13 Suppl 1
DP  - 1996
TI  - Findings from the Miyazaki Cohort Study.
PG  - S2-7
AB  - The purpose of the Miyazaki Cohort Study is to describe and analyze the natural 
      history of human T-cell lymphotropic virus type I (HTLV-I) in a highly endemic 
      population in southwestern Japan. As of August 1995, 1,960 individuals have been 
      enrolled, of whom 27% were HTLV-I antibody positive at baseline. Our achievements 
      over the past decade of following this cohort include the identification of 
      several viral markers that characterize high-risk carriers and the documentation 
      that carriers have subclinical evidence of impaired cellular immunity. We have 
      begun to estimate the impact of the infection on the health of carriers and have 
      found that men are at greater risk of HTLV-I-associated diseases than women. We 
      have been able to identify prospectively risk factors associated with sexual 
      transmission. Most important, by identifying subclinical markers of pathogenesis, 
      we hope to provide the foundation for developing interventions to prevent 
      HTLV-I-associated disease.
FAU - Mueller, N
AU  - Mueller N
AD  - Department of Epidemiology, Harvard School of Public Health, Boston, 
      Massachusetts 02115, USA.
FAU - Okayama, A
AU  - Okayama A
FAU - Stuver, S
AU  - Stuver S
FAU - Tachibana, N
AU  - Tachibana N
LA  - eng
GR  - R37 CA38450/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Acquir Immune Defic Syndr Hum Retrovirol
JT  - Journal of acquired immune deficiency syndromes and human retrovirology : 
      official publication of the International Retrovirology Association
JID - 9501482
RN  - 0 (Biomarkers)
RN  - 0 (Deltaretrovirus Antibodies)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - Carrier State/virology
MH  - Deltaretrovirus Antibodies/analysis
MH  - Disease Transmission, Infectious
MH  - Female
MH  - HTLV-I Infections/*epidemiology/immunology/transmission
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Rural Population
MH  - Sex Factors
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1097/00042560-199600001-00002 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S2-7. doi: 
      10.1097/00042560-199600001-00002.