PMID- 8797700
OWN - NLM
STAT- MEDLINE
DCOM- 19961029
LR  - 20191024
IS  - 1077-9450 (Print)
IS  - 1077-9450 (Linking)
VI  - 13 Suppl 1
DP  - 1996
TI  - HAM/TSP: recent perspectives in Japan.
PG  - S26-32
AB  - Neurologic diseases associated with human T-cell lymphotropic virus type I 
      (HTLV-I) infection have a clinical spectrum that includes myelopathy 
      (HTLV-I-associated myelopathy/tropical spastic paraparesis, HAM/TSP) as the 
      central manifestation. Many clinical signs of involvement outside the central 
      nervous system (CNS) have been described in some patients with HAM/TSP and have 
      triggered and advanced the discovery of some HTLV-I-associated concepts in 
      HTLV-I-infected individuals without signs of CNS involvement. Most of these 
      HTLV-I-associated diseases exhibit common viroimmunologic characteristics that 
      include a distributional bias of HTLV-I activation between the blood flow and the 
      affected lesions and accumulated cellular immune responses in the lesions. These 
      facts suggest that the vulnerable tissue(s) in some HTLV-I-infected individuals 
      may not be defined by an exclusive tissue specificity, but that common steps of 
      HTLV-I-versus-host interactions may have an important role in the pathologic 
      process(es) in these diseases. This review summarizes the recent perspectives of 
      the clinical spectrum and the pathogenesis of HAM/TSP in Japan. Furthermore, the 
      feasible pathogenic involvement of cellular interactions between infected cells 
      and responding immunocompetent cells in the affected tissues is emphasized.
FAU - Ijichi, S
AU  - Ijichi S
AD  - Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 
      Japan.
FAU - Nakagawa, M
AU  - Nakagawa M
FAU - Umehara, F
AU  - Umehara F
FAU - Higuchi, I
AU  - Higuchi I
FAU - Arimura, K
AU  - Arimura K
FAU - Izumo, S
AU  - Izumo S
FAU - Osame, M
AU  - Osame M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Acquir Immune Defic Syndr Hum Retrovirol
JT  - Journal of acquired immune deficiency syndromes and human retrovirology : 
      official publication of the International Retrovirology Association
JID - 9501482
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/virology
MH  - Female
MH  - HTLV-I Infections/diagnosis/*etiology/virology
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/diagnosis/*etiology/virology
MH  - Polymyositis/virology
MH  - Sjogren's Syndrome/virology
MH  - Uveitis/virology
RF  - 61
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1097/00042560-199600001-00006 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S26-32. doi: 
      10.1097/00042560-199600001-00006.