PMID- 8797701
OWN - NLM
STAT- MEDLINE
DCOM- 19961029
LR  - 20191024
IS  - 1077-9450 (Print)
IS  - 1077-9450 (Linking)
VI  - 13 Suppl 1
DP  - 1996
TI  - Tropical spastic paraparesis/HTLV-I-associated myelopathy in Brazil.
PG  - S33-7
AB  - Brazil, the largest Latin American country, is highly heterogeneous, both 
      demographically and socioeconomically. The overall human T-cell lymphotropic 
      virus type I (HTLV-I) seroprevalence among blood donors is approximately 0.45%. 
      These rates are highly variable, from 0 to 1.8%. Since 1989, many series of 
      tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) cases have 
      appeared in the literature, with high variation in the prevalence of HTLV-I among 
      TSP patients (14.7-57%). The main clinical features of Brazilian TSP/HAM are 
      similar to those in other endemic countries, but sensory signs are more frequent. 
      Recently, the presence of peripheral nerve and muscular involvement has been 
      characterized. The first nationwide study on the disease has been recently 
      completed: it enrolled 163 patients and concluded that TSP/HAM is common in 
      Brazil, mainly in the northeast and southeast regions; it predominates among 
      women and whites; the most important risk factors for infection are sexual 
      promiscuity and blood transfusion; and, although a remarkably uniform disease 
      throughout the country, some statistically significant differences were detected, 
      such as a higher proportion of females over males in the northeast region, a 
      higher proportion of whites the southeast and the south and mulattos in the 
      northeast, and, finally, a high rate of venereal diseases in the southeast region 
      and of intravenous drug use in the south. Brazil seems to be a perfect setting 
      for future epidemiologic, clinical, basic, and therapeutic studies on TSP/HAM.
FAU - Araujo, A de Q
AU  - Araujo Ade Q
AD  - HTLV Unit, Evandro Chagas Hospital, Oswaldo Cruz Institute, Rio de Janeiro, 
      Brazil.
FAU - de Andrada-Serpa, M J
AU  - de Andrada-Serpa MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Acquir Immune Defic Syndr Hum Retrovirol
JT  - Journal of acquired immune deficiency syndromes and human retrovirology : 
      official publication of the International Retrovirology Association
JID - 9501482
SB  - IM
MH  - Blood Donors
MH  - Blood Transfusion
MH  - Brazil
MH  - Female
MH  - HTLV-I Infections/diagnosis/*epidemiology/transmission
MH  - Humans
MH  - Male
MH  - Paraparesis, Tropical Spastic/diagnosis/*epidemiology/transmission
MH  - Seroepidemiologic Studies
MH  - Sexually Transmitted Diseases/virology
MH  - Substance Abuse, Intravenous/virology
RF  - 39
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1097/00042560-199600001-00007 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S33-7. doi: 
      10.1097/00042560-199600001-00007.