PMID- 8797702
OWN - NLM
STAT- MEDLINE
DCOM- 19961029
LR  - 20191024
IS  - 1077-9450 (Print)
IS  - 1077-9450 (Linking)
VI  - 13 Suppl 1
DP  - 1996
TI  - Tropical spastic paraparesis/HTLV-I-associated myelopathy in Europe and in 
      Africa: clinical and epidemiologic aspects.
PG  - S38-45
AB  - We review here the epidemiologic and clinical aspects of tropical spastic 
      paraparesis, human T-cell lymphotropic virus type I (HTLV-I)-associated 
      myelopathy (TSP/HAM) as observed in Europe and in Africa. Europe is not an 
      endemic region for HTLV-I (seroprevalence in blood donors, < 0.03%), and TSP/HAM 
      is thus rarely observed in European countries. Most of the few patients suffering 
      from TSP/HAM are first- or second-generation immigrants from HTLV-I endemic areas 
      (mostly the West Indies), and the clinicoepidemiologic aspects of these patients 
      are similar to those seen in endemic areas. However, rare cases occur in 
      European-born subjects with or without risk factors for HTLV-I infection, which 
      raises the possibility of limited foci areas in Europe. Although Africa is 
      considered as a primary HTLV-I endemic area, with at least a few million infected 
      inhabitants, epidemiologic data on the situation of TSP/HAM in Africa remain 
      scarce. Relatively few cases of patients with TSP/HAM have been reported in 
      Africa, including some clusters in Zaire (prevalence, 50/100,000) and in South 
      Africa and sporadically in the main cities of some Western, Central, and Eastern 
      African countries. The paucity of clinical and epidemiologic data on TSP/HAM may 
      be linked to several factors, including the paucity of neurologists, the lack of 
      laboratory and radiologic facilities, and the chronicity of the disease, along 
      with the limited number of field epidemiologic studies performed on this topic 
      and the wide diversity of causes (toxic, nutritional, and infectious) of chronic 
      myelopathies as seen on the African continent.
FAU - Touze, E
AU  - Touze E
AD  - Federation de Neurologie, Hopital de la Pitie-Salpetriere, Paris, France.
FAU - Gessain, A
AU  - Gessain A
FAU - Lyon-Caen, O
AU  - Lyon-Caen O
FAU - Gout, O
AU  - Gout O
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Acquir Immune Defic Syndr Hum Retrovirol
JT  - Journal of acquired immune deficiency syndromes and human retrovirology : 
      official publication of the International Retrovirology Association
JID - 9501482
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Africa, Eastern/epidemiology
MH  - Africa, Northern/epidemiology
MH  - Africa, Southern/epidemiology
MH  - Africa, Western/epidemiology
MH  - Blood Donors
MH  - Blood Transfusion
MH  - Emigration and Immigration/statistics & numerical data
MH  - Europe
MH  - Female
MH  - HTLV-I Infections/diagnosis/*epidemiology/etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/diagnosis/*epidemiology/etiology
MH  - Seroepidemiologic Studies
RF  - 71
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1097/00042560-199600001-00008 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S38-45. doi: 
      10.1097/00042560-199600001-00008.