PMID- 8797703
OWN - NLM
STAT- MEDLINE
DCOM- 19961029
LR  - 20191024
IS  - 1077-9450 (Print)
IS  - 1077-9450 (Linking)
VI  - 13 Suppl 1
DP  - 1996
TI  - HTLV-I-associated infective dermatitis: past, present, and future.
PG  - S46-9
AB  - Infective dermatitis (ID) of Jamaican children, a distinctive pattern of 
      dermatitis first described in Jamaican children in 1966 was found to be 
      associated with human T-cell lymphotropic virus type I (HTLV-I) infection in 
      1990. Since then, ID has been reported from other HTLV-I endemic areas. Further 
      studies have confirmed the HTLV-I association and have demonstrated immunologic 
      abnormalities in cellular and humoral immune systems as well as at the 
      subcellular level. Viral genome has been detected in cultured skin biopsy 
      material, and genetic factors may predispose people to the development of ID. 
      Transmission of HTLV-I infection in ID appears to be from mother to infant via 
      breast milk. Present therapy is with long-term antibiotics to control bacterial 
      infection and hence the dermatitis. Complications are frequent and include 
      crusted scabies, corneal opacities, chronic bronchiectasis, parasitic worm 
      infestation, early death, and progression to more severe HTLV-I-associated 
      disorders such as adult T-cell leukemia/lymphoma and HTLV-I-associated 
      myelopathy/tropical spastic paraparesis. Future studies are planned to determine 
      the precise immunologic defect, the role of socioeconomic and nutritional 
      factors, and the natural history. Intervention studies to limit breast feeding 
      and hence HTLV-I transmission are also planned.
FAU - La Grenade, L
AU  - La Grenade L
AD  - Department of Medicine, University of the West Indies, Mona, Jamaica.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Acquir Immune Defic Syndr Hum Retrovirol
JT  - Journal of acquired immune deficiency syndromes and human retrovirology : 
      official publication of the International Retrovirology Association
JID - 9501482
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibody Formation
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis/*virology
MH  - Female
MH  - Genome, Viral
MH  - HTLV-I Infections/*history/transmission
MH  - History, 20th Century
MH  - Humans
MH  - Immunity, Cellular
MH  - Infant
MH  - Jamaica
MH  - Male
MH  - Skin/virology
RF  - 17
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1097/00042560-199600001-00009 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S46-9. doi: 
      10.1097/00042560-199600001-00009.