PMID- 8800093
OWN - NLM
STAT- MEDLINE
DCOM- 19961022
LR  - 20240109
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 55
IP  - 9
DP  - 1996 Sep
TI  - The glial and mesenchymal elements of gliosarcomas share similar genetic 
      alterations.
PG  - 973-81
AB  - The cellular origin of the sarcomatous component of gliosarcomas is 
      controversial. It is not clear if the sarcoma arises in transition from the glial 
      cells that comprise the gliomatous component or independently arises from 
      non-neoplastic mesenchymal cells of the tumor stroma. Using comparative genomic 
      hybridization (CGH) along with cytogenetic analysis, fluorescence in situ 
      hybridization (FISH) analysis, and polymerase chain reaction (PCR) analysis of 
      microsatellite allelic imbalance, we have evaluated the genetic alterations in 
      the gliomatous and sarcomatous components of five gliosarcomas. The glial element 
      was grade 4 fibrillary astrocytoma (glioblastoma multiforme) in all five tumors. 
      The sarcoma elements were fibroblastic without osseous, chondroid, or 
      angiosarcomatous differentiation. Gain of chromosome 7, loss of chromosome 10, 
      deletions of the chromosome 9 p-arm, and alterations of chromosome 3 were 
      frequently observed, demonstrating that gliosarcomas can be genetically 
      classified as belonging to the spectrum of glioblastomas. Furthermore, the 
      sarcomatous and gliomatous portions of each gliosarcoma investigated were similar 
      with respect to both the presence and absence of specific genetic alterations. 
      This observation supports the hypothesis that the sarcomatous component of a 
      gliosarcoma either arises from the same common precursor cell as the gliomatous 
      portion, or it arises from the gliomatous portion itself.
FAU - Boerman, R H
AU  - Boerman RH
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 
      Minnesota 55905, USA.
FAU - Anderl, K
AU  - Anderl K
FAU - Herath, J
AU  - Herath J
FAU - Borell, T
AU  - Borell T
FAU - Johnson, N
AU  - Johnson N
FAU - Schaeffer-Klein, J
AU  - Schaeffer-Klein J
FAU - Kirchhof, A
AU  - Kirchhof A
FAU - Raap, A K
AU  - Raap AK
FAU - Scheithauer, B W
AU  - Scheithauer BW
FAU - Jenkins, R B
AU  - Jenkins RB
LA  - eng
GR  - CA50905/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (DNA, Neoplasm)
RN  - 0 (DNA, Satellite)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - DNA Mutational Analysis
MH  - DNA, Neoplasm/analysis
MH  - DNA, Satellite/analysis
MH  - Female
MH  - Gene Dosage
MH  - Gene Expression Regulation, Neoplastic/physiology
MH  - Gliosarcoma/*genetics/*pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mesoderm/*pathology
MH  - Middle Aged
MH  - Neuroglia/pathology/*physiology
MH  - Nucleic Acid Hybridization
MH  - Paraffin Embedding
MH  - Stem Cells/pathology/physiology
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1097/00005072-199609000-00004 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 1996 Sep;55(9):973-81. doi: 
      10.1097/00005072-199609000-00004.