PMID- 8800368
OWN - NLM
STAT- MEDLINE
DCOM- 19961205
LR  - 20131121
IS  - 0001-6772 (Print)
IS  - 0001-6772 (Linking)
VI  - 157
IP  - 2
DP  - 1996 Jun
TI  - Intracerebroventricular angiotensin II increases tolerance to blood loss in 
      conscious sheep.
PG  - 265-74
AB  - Intracerebroventricular (i.c.v.) infusion of hypertonic NaCl improves the 
      tolerance to haemorrhage in sheep. Since i.c.v. angiotensin II (ANG II) shares 
      many of the effects of hypertonic NaCl on fluid balance control and blood 
      pressure, we aimed to determine whether i.c.v. ANG II would also be effective in 
      that regard. Six adult conscious ewes were bled from the jugular vein until the 
      mean arterial pressure suddenly dropped to between 45 and 50 mmHg, during an 
      i.c.v. infusion of ANG II (2 pmol kg-1 min-1) which commenced 30 min prior to 
      start of blood removal and continued until end of retransfusion about 80 min 
      after haemorrhage. A corresponding haemorrhage in the same animals during an 
      i.c.v. infusion of 0.9% NaCl served as controls. Significantly more blood had to 
      be withdrawn to induce hypotension when ANG II was given i.c.v. (22.3 +/- 1.8 vs. 
      12.6 +/- 1.2 mL kg-1). The degree of hypotension and the recovery rate of the 
      blood pressure did not differ between the experiments. The increased tolerance to 
      blood loss by ANG II i.c.v. was accompanied by a reinforced elevation of the 
      systemic vascular resistance and a larger decline of the cardiac output. The 
      plasma norepinephrine concentration was significantly increased immediately after 
      haemorrhage during i.c.v. ANG II, but not in control experiments. The overall 
      vasopressin response to the hypotensive blood loss was not affected by ANG II, 
      but high plasma levels were obtained already during the non-hypotensive stage of 
      haemorrhage. The i.c.v. infusion of ANG II caused a significant lowering of the 
      plasma protein concentration before start of bleeding and accentuated the 
      haemodilution caused by the haemorrhage. We conclude that central administration 
      of ANG II increases the tolerance to haemorrhage in sheep but with concomitant 
      haemodynamic changes which appear unfavourable regarding cardiac load and tissue 
      perfusion.
FAU - Ullman, J E
AU  - Ullman JE
AD  - Department of Anaesthesiology, Karolinska Hospital, Stockholm, Sweden.
FAU - Hjelmqvist, H
AU  - Hjelmqvist H
FAU - Rundgren, M
AU  - Rundgren M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Physiol Scand
JT  - Acta physiologica Scandinavica
JID - 0370362
RN  - 0 (Blood Proteins)
RN  - 0 (Vasoconstrictor Agents)
RN  - 11000-17-2 (Vasopressins)
RN  - 11128-99-7 (Angiotensin II)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 3.4.23.15 (Renin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Angiotensin II/administration & dosage/*pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects/physiology
MH  - Blood Proteins/metabolism
MH  - Cardiac Output/drug effects/physiology
MH  - Female
MH  - Hematocrit
MH  - Hemodynamics/drug effects
MH  - Hemorrhage/*physiopathology
MH  - Injections, Intraventricular
MH  - Norepinephrine/blood
MH  - Renin/blood
MH  - Sheep
MH  - Sodium/blood
MH  - Vascular Resistance/drug effects/physiology
MH  - Vasoconstrictor Agents/administration & dosage/*pharmacology
MH  - Vasopressins/blood
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 10.1046/j.1365-201X.1996.497242000.x [doi]
PST - ppublish
SO  - Acta Physiol Scand. 1996 Jun;157(2):265-74. doi: 
      10.1046/j.1365-201X.1996.497242000.x.