PMID- 8804340
OWN - NLM
STAT- MEDLINE
DCOM- 19961022
LR  - 20190630
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 129
IP  - 3
DP  - 1996 Sep
TI  - Effect of six months of growth hormone therapy, followed by treatment withdrawal 
      in short children with normal quantitative indexes of growth hormone secretion.
PG  - 456-8
AB  - Eight short patients with normal 24-hour integrated concentration of growth 
      hormone by continuous withdrawal (IC-GH) received 6 months of GH therapy, 
      followed by 6 months off. GH therapy increased growth rate (+2.9 cm/yr), repeated 
      IC-GH (sixfold), and IGF-1 concentration (twofold). Posttreatment growth reverted 
      to the pretreatment rate. Thus increased growth rate and IGF-1 concentration is 
      associated with supraphysiologic IC-GH after injection.
FAU - Chalew, S A
AU  - Chalew SA
AD  - Department of Pediatrics, University of Maryland School of Medicine, Baltimore 
      21201, USA.
FAU - Phillip, M
AU  - Phillip M
FAU - Kowarski, A A
AU  - Kowarski AA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Growth
MH  - Growth Disorders/blood/physiopathology/*therapy
MH  - Growth Hormone/*administration & dosage/metabolism
MH  - Humans
MH  - Insulin-Like Growth Factor I/analysis
MH  - Male
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - S0022-3476(96)70083-5 [pii]
AID - 10.1016/s0022-3476(96)70083-5 [doi]
PST - ppublish
SO  - J Pediatr. 1996 Sep;129(3):456-8. doi: 10.1016/s0022-3476(96)70083-5.