PMID- 8805698
OWN - NLM
STAT- MEDLINE
DCOM- 19961017
LR  - 20101118
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 383
IP  - 6597
DP  - 1996 Sep 19
TI  - A genome-wide search for quantitative trait loci underlying asthma.
PG  - 247-50
AB  - Asthma now affects one child in seven in the United Kingdom. Most cases (95%) of 
      childhood asthma are associated with atopy, the immunoglobulin E (IgE)-mediated 
      familial syndrome of allergic asthma, eczema and rhinitis. Segregation analysis 
      has consistently suggested the presence of major genes influencing atopy and IgE 
      levels, with the expectation that these genes may be identified by positional 
      cloning or the examination of candidate genes. Here we report the results of a 
      genome-wide search for linkage to one qualitative and four quantitative traits 
      associated with allergic (atopic) asthma. We have identified six potential 
      linkages (P<0.001), five of which are to quantitative traits. Monte Carlo 
      simulations show that 1.6 false-positive linkages at this level of significance 
      would be expected from the data. One linkage, to chromosome 11q13, has been 
      established previously. Three of the new loci show evidence of linkage to a 
      second panel of families, in which maternal effects and pleiotropy of linked 
      phenotypes are seen. The results demonstrate the extent and the complexity of the 
      genetic predisposition to asthma.
FAU - Daniels, S E
AU  - Daniels SE
AD  - Wellcome Trust Centre for Human Genetic Disease, University of Oxford, UK.
FAU - Bhattacharrya, S
AU  - Bhattacharrya S
FAU - James, A
AU  - James A
FAU - Leaves, N I
AU  - Leaves NI
FAU - Young, A
AU  - Young A
FAU - Hill, M R
AU  - Hill MR
FAU - Faux, J A
AU  - Faux JA
FAU - Ryan, G F
AU  - Ryan GF
FAU - le Souef, P N
AU  - le Souef PN
FAU - Lathrop, G M
AU  - Lathrop GM
FAU - Musk, A W
AU  - Musk AW
FAU - Cookson, W O
AU  - Cookson WO
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Genetic Markers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/*genetics
MH  - Child
MH  - Eosinophils
MH  - *Genetic Linkage
MH  - Genetic Markers
MH  - Genome, Human
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/genetics
MH  - Leukocyte Count
MH  - Monte Carlo Method
MH  - Phenotype
MH  - Radioallergosorbent Test
MH  - Skin Tests
EDAT- 1996/09/19 00:00
MHDA- 1996/09/19 00:01
CRDT- 1996/09/19 00:00
PHST- 1996/09/19 00:00 [pubmed]
PHST- 1996/09/19 00:01 [medline]
PHST- 1996/09/19 00:00 [entrez]
AID - 10.1038/383247a0 [doi]
PST - ppublish
SO  - Nature. 1996 Sep 19;383(6597):247-50. doi: 10.1038/383247a0.