PMID- 8806799
OWN - NLM
STAT- MEDLINE
DCOM- 19961101
LR  - 20151119
IS  - 0008-8749 (Print)
IS  - 0008-8749 (Linking)
VI  - 171
IP  - 2
DP  - 1996 Aug 1
TI  - Histamine enhanced the TNF-alpha-induced expression of E-selectin and ICAM-1 on 
      vascular endothelial cells.
PG  - 285-8
AB  - Cell adhesion molecules are expressed on endothelial cells by various 
      proinflammatory cytokines. Tumor necrosis factor-alpha (TNF-alpha) induces the 
      expression of E-selectin and intercellular adhesion molecule-1 (ICAM-1) on human 
      umbilical vein endothelial cells (HUVEC). Although histamine is a potent 
      vasoactive mediator, it does not induce the expression of E-selectin and ICAM-1. 
      In this report, we show that histamine concentration-dependently enhances the 
      TNF-alpha-induced expression of E-selectin and ICAM-1 on HUVEC. The 
      histamine-enhanced expression of E-selectin and ICAM-1 was inhibited by the 
      histamine H1 receptor antagonists, mepyramine and diphenhydramine. KW-4679 and 
      ketotifen, antiallergic drugs with histamine H1 receptor antagonistic activity, 
      potently inhibit the expression of E-selectin and ICAM-1. A histamine H2 receptor 
      antagonist, ranitidine, did not affect the histamine-induced expression of cell 
      adhesion molecules. These data indicate that histamine induces the expression of 
      E-selectin and ICAM-1 synergistically with TNF-alpha through histamine H1 
      receptors.
FAU - Miki, I
AU  - Miki I
AD  - Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, 
      Japan.
FAU - Kusano, A
AU  - Kusano A
FAU - Ohta, S
AU  - Ohta S
FAU - Hanai, N
AU  - Hanai N
FAU - Otoshi, M
AU  - Otoshi M
FAU - Masaki, S
AU  - Masaki S
FAU - Sato, S
AU  - Sato S
FAU - Ohmori, K
AU  - Ohmori K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Dibenzoxepins)
RN  - 0 (E-Selectin)
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 2XG66W44KF (Olopatadine Hydrochloride)
RN  - 820484N8I3 (Histamine)
RN  - 884KT10YB7 (Ranitidine)
RN  - 8GTS82S83M (Diphenhydramine)
RN  - HPE317O9TL (Pyrilamine)
RN  - X49220T18G (Ketotifen)
SB  - IM
MH  - Animals
MH  - CHO Cells
MH  - Cells, Cultured
MH  - Cricetinae
MH  - Dibenzoxepins/pharmacology
MH  - Diphenhydramine/pharmacology
MH  - Drug Interactions
MH  - E-Selectin/*biosynthesis
MH  - Endothelium, Vascular/cytology/drug effects/*immunology
MH  - Histamine/*pharmacology
MH  - Histamine H1 Antagonists/pharmacology
MH  - Histamine H2 Antagonists/pharmacology
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*biosynthesis
MH  - Ketotifen/pharmacology
MH  - Olopatadine Hydrochloride
MH  - Pyrilamine/pharmacology
MH  - Ranitidine/pharmacology
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Umbilical Veins
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - S0008-8749(96)90205-1 [pii]
AID - 10.1006/cimm.1996.0205 [doi]
PST - ppublish
SO  - Cell Immunol. 1996 Aug 1;171(2):285-8. doi: 10.1006/cimm.1996.0205.