PMID- 8806963
OWN - NLM
STAT- MEDLINE
DCOM- 19961204
LR  - 20190905
IS  - 0193-1091 (Print)
IS  - 0193-1091 (Linking)
VI  - 18
IP  - 3
DP  - 1996 Jun
TI  - Immunohistochemical study of CD34-positive dendritic cells of human dermis.
PG  - 283-8
AB  - The human dermis contains a heterogeneous network of cells with a dendritic 
      morphology, including factor XIIIa+ dermal dendrocytes and CD34+ dendritic cells 
      located around epidermal adnexae. Whereas dermal dendrocytes have been 
      immunohistochemically studied, CD34+ dermal cells have not yet been well 
      characterized. We studied by simple and double immunolabeling techniques on 
      tissue sections of normal human skin the phenotype of these cells and found them 
      to express vimentin and Te7 but none of the remaining markers sought (factor 
      XIIIa, von Willebrand factor, CD1a, CD3, CD4, CD8, CD14, CD25, CD36, CD45, CD54, 
      CD56, LFA-1, EGF-R, S-100 protein, Mac 387, and muscle-specific actin). Rare 
      CD34+ cells of the interstitial dermis expressed human leukocyte antigen (HLA)-DR 
      antigens, but this was not the case for periadnexal CD34+ cells. These results 
      show that CD34+ dendritic cells of human dermis are mesenchymal cells bearing a 
      unique immunophenotype different from that of (myo)fibroblasts, 
      monocytes-macrophages, Langerhans cells, and factor XIIIa+ dermal dendrocytes. 
      Whereas the involvement of CD34+ cells in some cutaneous tumors is well known, 
      their physiologic role in normal skin remains to be established. On the basis of 
      our results, we speculate that these cells could represent uncommitted 
      mesenchymal cells, unique by virtue of CD34 antigen expression.
FAU - Narvaez, D
AU  - Narvaez D
AD  - Department of Dermatology, Ed. Herriot Hospital, Lyon, France.
FAU - Kanitakis, J
AU  - Kanitakis J
FAU - Faure, M
AU  - Faure M
FAU - Claudy, A
AU  - Claudy A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Dermatopathol
JT  - The American Journal of dermatopathology
JID - 7911005
RN  - 0 (Actins)
RN  - 0 (Antigens, CD1)
RN  - 0 (Antigens, CD34)
RN  - 0 (CD3 Complex)
RN  - 0 (CD36 Antigens)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD56 Antigen)
RN  - 0 (CD8 Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Lymphocyte Function-Associated Antigen-1)
RN  - 0 (Receptors, Interleukin-2)
RN  - 0 (S100 Proteins)
RN  - 0 (Vimentin)
RN  - 0 (von Willebrand Factor)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
CIN - Am J Dermatopathol. 1998 Oct;20(5):533-6. PMID: 9790122
MH  - Actins/analysis
MH  - Antigens, CD1/analysis
MH  - Antigens, CD34/*analysis
MH  - CD3 Complex/analysis
MH  - CD36 Antigens/analysis
MH  - CD4 Antigens/analysis
MH  - CD56 Antigen/analysis
MH  - CD8 Antigens/analysis
MH  - Dendritic Cells/*cytology/immunology
MH  - ErbB Receptors/analysis
MH  - Fibroblasts/cytology
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - Intercellular Adhesion Molecule-1/analysis
MH  - Leukocyte Common Antigens/analysis
MH  - Lipopolysaccharide Receptors/analysis
MH  - Lymphocyte Function-Associated Antigen-1/analysis
MH  - Macrophages/cytology
MH  - Monocytes/cytology
MH  - Receptors, Interleukin-2/analysis
MH  - S100 Proteins/analysis
MH  - Skin/*cytology/immunology
MH  - Transglutaminases/analysis
MH  - Vimentin/analysis
MH  - von Willebrand Factor/analysis
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 10.1097/00000372-199606000-00008 [doi]
PST - ppublish
SO  - Am J Dermatopathol. 1996 Jun;18(3):283-8. doi: 10.1097/00000372-199606000-00008.