PMID- 8807622
OWN - NLM
STAT- MEDLINE
DCOM- 19961114
LR  - 20131121
IS  - 0378-0392 (Print)
IS  - 0378-0392 (Linking)
VI  - 22
IP  - 4
DP  - 1996
TI  - Does the plasma concentration of 25-hydroxyvitamin D determine the level of 
      1,25-dihydroxyvitamin D in primary hyperparathyroidism?
PG  - 203-6
AB  - In man, parathyroid hormone (PTH) is one of the main regulators of 
      1,25-dihydroxyvitamin D (1,25(OH)2D) production. However, conflicting results 
      have been reported concerning the regulatory significance of PTH on 1,25(OH)2D in 
      primary hyperparathyroidism. We measured the plasma concentrations of intact PTH, 
      ionized calcium (pH 7.4), phosphate, creatinine, 25-hydroxyvitamin D (25(OH)D), 
      1,25(OH)2D and urine creatinine in a standardised regime in 17 patients with 
      primary hyperparathyroidism. The nephrogeneous cyclic adenosine-3,5-monophosphate 
      (NcAMP) was measured and so provides an "in vivo receptor assay' for biologically 
      active PTH in the circulation. Multiple regression analysis was used to identify 
      variables with a possible influence on the plasma concentration of 1,25(OH)2D. 
      The only variable showing a significant correlation to the plasma concentration 
      of 1,25(OH)2D was 25(OH)D (r=0.6, p < 0.03). Our results indicate that the plasma 
      concentration of 25(OH)D may be very central for the regulation of 1,25(OH)2D 
      production in primary hyperparathyroidism.
FAU - Frolich, A
AU  - Frolich A
AD  - Department of Clinical Chemistry, KAS Herlev, University of Copenhagen, Gentofte, 
      Denmark.
FAU - Storm, T
AU  - Storm T
FAU - Thode, J
AU  - Thode J
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Miner Electrolyte Metab
JT  - Mineral and electrolyte metabolism
JID - 7802196
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Phosphates)
RN  - AYI8EX34EU (Creatinine)
RN  - E0399OZS9N (Cyclic AMP)
RN  - FXC9231JVH (Calcitriol)
RN  - P6YZ13C99Q (Calcifediol)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Calcifediol/*blood
MH  - Calcitriol/*blood
MH  - Calcium/blood
MH  - Creatinine/blood
MH  - Cyclic AMP/blood
MH  - Female
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Hyperparathyroidism/*blood
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Hormone/blood
MH  - Phosphates/blood
MH  - Regression Analysis
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PST - ppublish
SO  - Miner Electrolyte Metab. 1996;22(4):203-6.