PMID- 8808158
OWN - NLM
STAT- MEDLINE
DCOM- 19970116
LR  - 20191210
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 53
IP  - 2
DP  - 1996 Feb
TI  - Effects of (+)-fenfluramine on 3,4-methylenedioxymethamphetamine (MDMA) 
      discrimination in rats.
PG  - 455-61
AB  - This study examined the effects of a presumed neurotoxic dose regimen of 
      (+)-fenfluramine on the discrimination of MDMA and (+)-amphetamine in male 
      Sprague-Dawley rats trained to discriminate 1.5 mg/kg MDMA from saline in a 
      two-choice operant task. Substitution tests were conducted with saline, several 
      doses of MDMA (0.19-1.5 mg/kg), and (+)-amphetamine (0.125-1.0 mg/kg) prior to 
      and again following the administration of (+)-fenfluramine (4.0 mg/kg twice a day 
      for 4 days; n = 11) or a similar pattern of saline injections (n = 10). During 
      pretreatment substitution tests, lower doses of MDMA elicited drug-appropriate 
      responding in a dose-dependent manner, although none of these doses substituted 
      for the training dose. Likewise, no dose of (+)-amphetamine substituted for the 
      training drug during pretreatment substitution tests. The discrimination of MDMA 
      was disrupted in some animals following (+)-fenfluramine treatment, but with 
      subsequent training, discrimination criteria were met. In posttreatment 
      substitution tests, the lowest dose of MDMA produced significantly higher 
      drug-appropriate responding in (+)-fenfluramine treated animals but not in 
      saline-treated animals. The amount of drug-appropriate responding during 
      posttreatment substitution tests with (+)-amphetamine varied little from 
      pretreatment substitution tests in saline-treated animals, but was greater at all 
      doses in (+)-fenfluramine-treated animals; the highest dose of (+)-amphetamine 
      substituted for MDMA subsequent to (+)-fenfluramine treatment. These results 
      support previous findings that the long-lasting serotonergic effects of 
      fenfluramine may have functional consequences that can be detected using a drug 
      discrimination procedure. Specifically, serotonin depletion may unmask or 
      strengthen the stimulant-like effects of MDMA.
FAU - Baker, L E
AU  - Baker LE
AD  - Department of Psychology, Western Michigan University, Kalamazoo 49008, USA.
FAU - Makhay, M M
AU  - Makhay MM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Dopamine Agents)
RN  - 0 (Serotonin Agents)
RN  - 2DS058H2CF (Fenfluramine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Dextroamphetamine/pharmacology
MH  - Discrimination, Psychological/*drug effects
MH  - Dopamine Agents/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Fenfluramine/*pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reinforcement Schedule
MH  - Serotonin Agents/*pharmacology
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 0091-3057(95)02017-9 [pii]
AID - 10.1016/0091-3057(95)02017-9 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1996 Feb;53(2):455-61. doi: 
      10.1016/0091-3057(95)02017-9.