PMID- 8809112
OWN - NLM
STAT- MEDLINE
DCOM- 19961028
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1308
IP  - 3
DP  - 1996 Sep 11
TI  - Structure, mapping and expression of a human NOR-1 gene, the third member of the 
      Nur77/NGFI-B family.
PG  - 205-14
AB  - We identified a human homologue of NOR-1 (neuron-derived orphan receptor) from 
      the fetal brain. There are two transcripts for human NOR-1, encoding 626 amino 
      acid residues with a calculated molecular mass of 68 kDa. The high homology 
      between hNOR-1, mNur77/rNGFI-B/hTR3, and mNurr1/rRNR-1/hNOT indicated that these 
      three orphan receptors form a distinct subfamily within the steroid/thyroid 
      receptor superfamily. Human NOR-1 mRNA was detected in the adult heart and 
      skeletal muscle as well as in the fetal brain, indicating that its expression is 
      not restricted to events that occur during neural development. The hNOR-1 gene is 
      more than 35 kilobases long and interrupted by seven introns. The exon-intron 
      structure of the gene is generally conserved when compared with the 
      steroid/thyroid receptor superfamily and is remarkably similar to that of the 
      Nur77/NGFI-B genes. This suggests that the Nur77/NGFI-B family has evolved from a 
      common ancestral gene. Fluorescence in situ hybridization (FISH) revealed that 
      the gene is located on chromosome 9q.
FAU - Ohkura, N
AU  - Ohkura N
AD  - Institute of Biomedical Science, TERUMO R&D Center, Kanagawa, Japan.
FAU - Ito, M
AU  - Ito M
FAU - Tsukada, T
AU  - Tsukada T
FAU - Sasaki, K
AU  - Sasaki K
FAU - Yamaguchi, K
AU  - Yamaguchi K
FAU - Miki, K
AU  - Miki K
LA  - eng
SI  - GENBANK/D78579
PT  - Journal Article
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (DNA Primers)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NR4A1 protein, human)
RN  - 0 (NR4A3 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nuclear Receptor Subfamily 4, Group A, Member 1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Blotting, Southern
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 9/genetics
MH  - Cloning, Molecular
MH  - DNA Primers
MH  - DNA-Binding Proteins/chemistry/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/chemistry/*genetics
MH  - Neuroblastoma/chemistry
MH  - Nuclear Receptor Subfamily 4, Group A, Member 1
MH  - RNA, Messenger/analysis/genetics
MH  - Receptors, Cytoplasmic and Nuclear
MH  - Receptors, Steroid/chemistry/*genetics
MH  - Receptors, Thyroid Hormone/chemistry/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors/chemistry/*genetics
MH  - Transcription, Genetic
MH  - Tumor Cells, Cultured
EDAT- 1996/09/11 00:00
MHDA- 1996/09/11 00:01
CRDT- 1996/09/11 00:00
PHST- 1996/09/11 00:00 [pubmed]
PHST- 1996/09/11 00:01 [medline]
PHST- 1996/09/11 00:00 [entrez]
AID - 0167-4781(96)00101-7 [pii]
AID - 10.1016/0167-4781(96)00101-7 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1996 Sep 11;1308(3):205-14. doi: 
      10.1016/0167-4781(96)00101-7.