PMID- 8810231
OWN - NLM
STAT- MEDLINE
DCOM- 19961211
LR  - 20151008
IS  - 0029-0203 (Print)
IS  - 0029-0203 (Linking)
VI  - 100
IP  - 8
DP  - 1996 Aug
TI  - [Physiological roles of rhodopsin phosphorylation and dephosphorylation and its 
      relationship with retinitis pigmentosa].
PG  - 575-81
AB  - Light signals are converted into electrical signals by vertebrate photoreceptor 
      cells, and the generated electrical signals are then modulated within retinal 
      neurons and brain. During the visual transduction precesses in the photoreceptor 
      cells, there are basically three functions. That is, (1) photoexcitation, (2) 
      quenching of the photoexcitation, and (3) adaptation. These functions are 
      precisely regulated by enzymatic cascade reactions. Quite recently, it was shown 
      that rhodopsin phosphorylation occurred at different sites with different 
      kinetics, in vivo, and this may be a control mechanism for both quenching and 
      adaptation. Furthermore, autosmal retinitis pigmentosa (RP) with rhodopsin 
      mutation at 296 Lys, which in the binding site of 11-cis-retinal, showed 
      constitutive activation of guanosine 5'-triphosphate (GTP) binding protein and no 
      rhodopsin phosphorylation by rhodopsin kinase. These observations suggest that 
      rhodopsin phosphorylation and dephosphorylation are critical for understanding 
      visual transduction and pathophysiology of RP.
FAU - Oguro, H
AU  - Oguro H
AD  - Department of Opthalmology, Sapporo Medical University School of Medicine, 
      Hokkaido, Japan.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nippon Ganka Gakkai Zasshi
JT  - Nippon Ganka Gakkai zasshi
JID - 7505716
RN  - 0 (Eye Proteins)
RN  - 9009-81-8 (Rhodopsin)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.14 (G-Protein-Coupled Receptor Kinase 1)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Adaptation, Ocular
MH  - Animals
MH  - Binding Sites
MH  - *Eye Proteins
MH  - G-Protein-Coupled Receptor Kinase 1
MH  - GTP-Binding Proteins/metabolism
MH  - Mutation
MH  - Phosphorylation
MH  - Photic Stimulation
MH  - Photoreceptor Cells/*physiology
MH  - Protein Kinases
MH  - Retinitis Pigmentosa/*etiology
MH  - *Rhodopsin/genetics/physiology
MH  - Signal Transduction
RF  - 49
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
PST - ppublish
SO  - Nippon Ganka Gakkai Zasshi. 1996 Aug;100(8):575-81.