PMID- 8810931
OWN - NLM
STAT- MEDLINE
DCOM- 19961022
LR  - 20190905
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 240
IP  - 2
DP  - 1996 Aug
TI  - Low molecular weight heparins.
PG  - 63-72
AB  - Low molecular weight heparins (LMWHs) differ from unfractionated heparin (UFH) in 
      a number of characteristics, which is probably due to differences in molecular 
      weight distribution. From a clinical point of view the better subcutaneous 
      bioavailability and longer biological half-life are important, making it 
      sufficient to inject LMWHs once-daily only. For practical purposes it is also 
      important that LMWHs be used without monitoring. They are effective as 
      prophylaxis against postoperative venous thromboembolism after all types of 
      surgery; in most studies, more effective than UFH. In most studies, this effect 
      can be obtained safely and with less bleeding than with UFH. LMWHs compare 
      favourably with UFH for starting treatment of deep vein thrombosis, as well as an 
      anticoagulant during haemodialysis. Adverse effects such as thrombocytopenia and 
      osteoporosis are more common with UFH than with LMWHs. Studies evaluating whether 
      or not LMWHs can replace UFH in arterial diseases are still few with small sample 
      sizes. Thus further systematic research is needed.
FAU - Bergqvist, D
AU  - Bergqvist D
AD  - Department of Surgery, University Hospital, Uppsala, Sweden.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - *Heparin, Low-Molecular-Weight/adverse effects/pharmacology/therapeutic use
MH  - Humans
RF  - 99
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.1046/j.1365-2796.1996.494834000.x [doi]
PST - ppublish
SO  - J Intern Med. 1996 Aug;240(2):63-72. doi: 10.1046/j.1365-2796.1996.494834000.x.