PMID- 8812350
OWN - NLM
STAT- MEDLINE
DCOM- 19961219
LR  - 20181130
IS  - 0016-6480 (Print)
IS  - 0016-6480 (Linking)
VI  - 103
IP  - 2
DP  - 1996 Aug
TI  - Regulation of growth hormone secretion by amino acid neurotransmitters in the 
      goldfish (I): Inhibition by N-methyl-D, L-aspartic acid.
PG  - 129-37
AB  - High levels of the amino acid neurotransmitter glutamate were found in the 
      goldfish hypothalamus and pituitary using high performance liquid chromatography 
      with fluorometric detection. A specific polyclonal antibody to glutamate was 
      generated in the rabbit for immunocytochemistry. Localization studies 
      demonstrated that glutamatergic neurons of undetermined origin innervate the 
      particular part of the goldfish adenohypophysis where somatotrophs and 
      gonadotrophs are located. Intraperitoneal and brain third ventricle injection of 
      the glutamate agonist N-methyl-D,L-aspartic acid (NMA) inhibited GH release in 
      vivo. The gonadal steroid estradiol plays an important role in regulating GH 
      secretion by stimulating basal serum GH levels and enhancing the inhibitory 
      effects of NMA on GH secretion. Taken together, these results demonstrate that 
      glutamate is an important regulator of GH secretion in goldfish.
FAU - Trudeau, V L
AU  - Trudeau VL
AD  - Department of Zoology, University of Aberdeen, Scotland.
FAU - Sloley, B D
AU  - Sloley BD
FAU - Kah, O
AU  - Kah O
FAU - Mons, N
AU  - Mons N
FAU - Dulka, J G
AU  - Dulka JG
FAU - Peter, R E
AU  - Peter RE
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 4TI98Z838E (Estradiol)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Animals
MH  - Estradiol/pharmacology
MH  - Glutamic Acid/analysis/*pharmacology
MH  - Goldfish/*physiology
MH  - Growth Hormone/*metabolism
MH  - Immunohistochemistry
MH  - Injections, Intraventricular
MH  - N-Methylaspartate/administration & dosage/*pharmacology
MH  - Pituitary Gland/chemistry
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - S0016-6480(96)90103-3 [pii]
AID - 10.1006/gcen.1996.0103 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 1996 Aug;103(2):129-37. doi: 10.1006/gcen.1996.0103.