PMID- 8814267
OWN - NLM
STAT- MEDLINE
DCOM- 19961024
LR  - 20181130
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 26
IP  - 9
DP  - 1996 Sep
TI  - Opposite effects of interleukin-13 and interleukin-12 on the release of 
      inflammatory cytokines, cytokine inhibitors and prostaglandin E from synovial 
      fibroblasts and blood mononuclear cells.
PG  - 2198-2202
AB  - We examined the effects of interleukin-12 (IL-12) and interleukin-13 (IL-13) on 
      cytokine, cytokine inhibitor and prostaglandin E (PGE) release from synovial 
      fibroblasts and blood mononuclear cells (MNC). In resting synovial fibroblasts, 
      we found that IL-13 is an inhibitor of IL-8 and PGE release. A significant 
      decrease of PGE synthesis caused by IL-13 was also observed in tumor necrosis 
      factor (TNF)-alpha-stimulated synovial fibroblasts, whereas IL-12 had no 
      regulatory effects on these cells. In resting and cytokine-stimulated MNC, IL-13 
      markedly inhibited IL-1 beta, IL-8 and monocyte chemoattractant protein-1 (MCP-1) 
      release and potently stimulated interleukin-1 receptor antagonist (IL-1ra) 
      synthesis. In contrast, IL-12 stimulated the production of IL-1 beta and MCP-1 in 
      TNF-alpha-stimulated MNC and inhibited IL-1ra synthesis in cytokine-stimulated 
      cells. These findings identify novel biological actions of IL-12 and IL-13 on 
      connective tissue and on blood mononuclear cells which indicate their regulatory 
      functions as enhancer and suppressor of inflammatory processes, respectively.
FAU - Seitz, M
AU  - Seitz M
AD  - Division of Rheumatology, University Hospital, Bern, Switzerland.
FAU - Loetscher, P
AU  - Loetscher P
FAU - Dewald, B
AU  - Dewald B
FAU - Towbin, H
AU  - Towbin H
FAU - Baggiolini, M
AU  - Baggiolini M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Cytokines)
RN  - 0 (IL1RN protein, human)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-8)
RN  - 0 (Prostaglandins E)
RN  - 0 (Sialoglycoproteins)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Cytokines/*metabolism
MH  - Fibroblasts/drug effects/metabolism
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-1/metabolism
MH  - Interleukin-12/*pharmacology
MH  - Interleukin-13/*pharmacology
MH  - Interleukin-8/biosynthesis/metabolism
MH  - Leukocytes, Mononuclear/drug effects/*metabolism
MH  - Prostaglandins E/*metabolism
MH  - Sialoglycoproteins/*metabolism
MH  - Synovial Membrane/cytology/metabolism
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1002/eji.1830260935 [doi]
PST - ppublish
SO  - Eur J Immunol. 1996 Sep;26(9):2198-2202. doi: 10.1002/eji.1830260935.