PMID- 8818300
OWN - NLM
STAT- MEDLINE
DCOM- 19970128
LR  - 20190914
IS  - 0514-7158 (Print)
IS  - 0514-7158 (Linking)
VI  - 43
IP  - 6
DP  - 1996 Aug
TI  - Histopathological findings in pigs of various ages suffering from spontaneous 
      infection with the porcine reproductive and respiratory syndrome virus (PRRSV).
PG  - 353-63
AB  - A retrospective study was carried out to investigate the morphology of 29 
      routinely necropsied German Landrace pigs of various ages, namely five fetuses, 
      eight neonates, five suckling piglets and 11 weaners, being either serologically 
      PRRSV-positive or born or aborted from PRRSV positive sows. Virus antigen was 
      immunohistochemically demonstrated in 12 out of 27 (44%) lungs tested. The 
      distinguishing histopathological features of PRRSV-induced spontaneous disease 
      are interstitial pneumonia accompanied by secondary inflammatory alterations that 
      become more and more pronounced with increasing age, and vascular alterations 
      hitherto not described in animals of these age groups. The latter consist of 
      vasculitis of the medium-sized arteries and occasionally of the veins, mainly in 
      the lungs but also in other organs, and of perivascular lymphoplasmacytic 
      infiltrates of various degrees of frequency and organ distribution, but present 
      above all in the CNS-including the meninges and in the lungs. These findings, 
      which suggest vasculotropism on the part of the PRRSV, may facilitate the 
      histopathological diagnosis of PRRSV infections in routinely examined material.
FAU - Darbes, J
AU  - Darbes J
AD  - Institute of Veterinary Pathology, University of Munich, Germany.
FAU - Hafner, A
AU  - Hafner A
FAU - Breuer, W
AU  - Breuer W
FAU - Hanichen, T
AU  - Hanichen T
FAU - Banholzer, E
AU  - Banholzer E
FAU - Hermanns, W
AU  - Hermanns W
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Zentralbl Veterinarmed A
JT  - Zentralblatt fur Veterinarmedizin. Reihe A
JID - 0331323
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Animals, Suckling
MH  - Fetal Diseases/pathology/*veterinary
MH  - Porcine Reproductive and Respiratory Syndrome/*pathology
MH  - Retrospective Studies
MH  - Swine
MH  - Weaning
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.1111/j.1439-0442.1996.tb00463.x [doi]
PST - ppublish
SO  - Zentralbl Veterinarmed A. 1996 Aug;43(6):353-63. doi: 
      10.1111/j.1439-0442.1996.tb00463.x.