PMID- 8820884
OWN - NLM
STAT- MEDLINE
DCOM- 19961030
LR  - 20190830
IS  - 0301-5548 (Print)
IS  - 0301-5548 (Linking)
VI  - 72
IP  - 3
DP  - 1996
TI  - Superoxide dismutase derivative prevents oxidative damage in liver and kidney of 
      rats induced by exhausting exercise.
PG  - 189-94
AB  - To prevent oxidative tissue damage induced by strenuous exercise in the liver and 
      kidney superoxide dismutase derivative (SM-SOD), which circulated bound to 
      albumin with a half-life of 6 h, was injected intraperitoneally into rats. 
      Exhausting treadmill running caused a significant increase in the activities of 
      xanthine oxidase (XO), and glutathione peroxidase (GPX) in addition to 
      concentrations of thiobarbituric acid-reactive substances (TBARS) in hepatic 
      tissue immediately after running. There was a definite increase in the 
      immunoreactive content of mitochondrial superoxide dismutase (Mn-SOD) 1 day after 
      the running. Meanwhile, the TBARS concentration in the kidney was markedly 
      elevated 3 days after running. The activities of GPX, and catalase in the kidney 
      increased significantly immediately and on days 1 and 3 following the test. The 
      immunoreactive content of Mn-SOD also increased 1 day after running. The exercise 
      induced no significant changes in immunoreactive Cu, Zn-SOD content in either 
      tissue. The administration of SM-SOD provided effective protection against lipid 
      peroxidation, and significantly attenuated the alterations in XO and all the 
      anti-oxidant enzymes, measured. In summary, the present data would suggest that 
      exhausting exercise may induce XO-derived oxidative damage in the liver, while 
      the increase in lipid peroxidation in the kidney might be the result of 
      washout-dependent accumulation of peroxidised metabolites. We found that the 
      administration of SM-SOD provided excellent protection against exercise-induced 
      oxidative stress in both liver and kidney.
FAU - Radak, Z
AU  - Radak Z
AD  - Laboratory of Exercise Physiology, University of Tsukuba, Japan.
FAU - Asano, K
AU  - Asano K
FAU - Inoue, M
AU  - Inoue M
FAU - Kizaki, T
AU  - Kizaki T
FAU - Oh-Ishi, S
AU  - Oh-Ishi S
FAU - Suzuki, K
AU  - Suzuki K
FAU - Taniguchi, N
AU  - Taniguchi N
FAU - Ohno, H
AU  - Ohno H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Appl Physiol Occup Physiol
JT  - European journal of applied physiology and occupational physiology
JID - 0410266
RN  - 0 (Antioxidants)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.17.3.2 (Xanthine Oxidase)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Kidney/enzymology/*pathology
MH  - Lipid Peroxidation/drug effects
MH  - Liver/enzymology/*pathology
MH  - Male
MH  - Oxidative Stress/*drug effects/physiology
MH  - Physical Exertion/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/chemistry/*pharmacology
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Xanthine Oxidase/metabolism
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1007/BF00838637 [doi]
PST - ppublish
SO  - Eur J Appl Physiol Occup Physiol. 1996;72(3):189-94. doi: 10.1007/BF00838637.