PMID- 8821330
OWN - NLM
STAT- MEDLINE
DCOM- 19961203
LR  - 20180216
IS  - 0304-324X (Print)
IS  - 0304-324X (Linking)
VI  - 41 Suppl 2
DP  - 1995
TI  - The effect of caloric restriction on lipofuscin accumulation in mouse brain with 
      age.
PG  - 173-85
AB  - Caloric restriction (CR), has been shown to extend average and maximum lifespan 
      in rodents and other animals as well as to delay a wide variety of manifestations 
      of aging. The purpose of this study was to further elucidate the relationship 
      between lipofuscin (LF) accumulation and the aging process by examining the 
      effect of lifelong CR on LF accumulation in brain cells. Specifically, 1) we 
      include age groups of CR (CR1 approximately equal to 90 kcal/wk and CR2 
      approximately equal to 58 kcal/wk) and ad libidum fed (AL; approximately 120 
      kcal/wk) mice including groups at maximum lifespan; 2) CR was the major dietary 
      manipulation; 3) LF was identified using EM; 4) LF was quantified by areal 
      measurement; and 5) the results were analyzed by inferential statistics. We have 
      found that 1) LF increased with age and 2) that animals in the CR2 group had 
      significantly less overall LF in the perikarya of the granule cells of the 
      dentate gyrus when compared to CR1 or AL animals at equivalent ages. In addition, 
      CR2 mice at maximum lifespan (45 mo.) had slightly less LF than did CR1 or AL 
      mice at their maximum lifespans (36 mo.). Our results clearly demonstrate that CR 
      (at 52%, but not 25% of AL diet) retards the overall accumulation of LF with time 
      and, further, suggest that LF accumulation is not simply a linear function of 
      age.
FAU - Moore, W A
AU  - Moore WA
AD  - Office of Post Grad Education, Clarke Institute of Psychiatry, Toronto, ON, 
      Canada.
FAU - Davey, V A
AU  - Davey VA
FAU - Weindruch, R
AU  - Weindruch R
FAU - Walford, R
AU  - Walford R
FAU - Ivy, G O
AU  - Ivy GO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Gerontology
JT  - Gerontology
JID - 7601655
RN  - 0 (Lipofuscin)
SB  - IM
MH  - Aging/*physiology
MH  - Analysis of Variance
MH  - Animals
MH  - *Brain/metabolism
MH  - *Diet, Reducing
MH  - Female
MH  - Lipofuscin/analysis/*metabolism
MH  - Mice
MH  - Mice, Inbred Strains
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1159/000213741 [doi]
PST - ppublish
SO  - Gerontology. 1995;41 Suppl 2:173-85. doi: 10.1159/000213741.