PMID- 8821480
OWN - NLM
STAT- MEDLINE
DCOM- 19961030
LR  - 20190830
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 91
IP  - 1
DP  - 1996 Jan 22
TI  - Pre- and postnatal development of the catecholamine innervation of the 
      hypoglossal nucleus in the rat: an immunocytochemical study.
PG  - 83-92
AB  - The pre- and postnatal development of the catecholamine (CA) innervation to the 
      hypoglossal nucleus (nXII) in the rat was investigated immunocytochemically with 
      antisera to tyrosine hydroxylase (TH). Immunoreactive profiles positive for TH 
      were first identified in nXII on gestational day (GD) 16. By GD 18, the 
      adult-like distribution pattern was evident, characterized by the preferential 
      targeting of the ventromedial region of nXII, but this pattern was not 
      consistently found in all fetuses until GD 19. From GD 19 to postnatal day (PD) 
      180, the overall density of TH immunoreactivity, particularly in the ventromedial 
      region, increased with further growth and maturation of nXII. These results 
      establish the early prenatal CA innervation of nXII and support the hypothesis 
      that CA are important in regulating motor tongue behavior in the newborn. 
      Moreover, because the ventral compartment of nXII contains motoneurons that 
      innervate protrusor muscles of the tongue, and tongue protrusor mechanisms play 
      an essential role in suckling, deglutition, and respiratory (maintaining a patent 
      upper airway) behaviors, it is further proposed that the CA innervation of nXII 
      is critical to the survival of the newborn.
FAU - Aldes, L D
AU  - Aldes LD
AD  - Department of Structural and Cellular Biology, University of South Alabama, 
      Mobile 36688, USA. laldes@jaguar1.usouthal.edu
FAU - Bartley, K
AU  - Bartley K
FAU - Royal, K
AU  - Royal K
FAU - Dixon, A
AU  - Dixon A
FAU - Chronister, R B
AU  - Chronister RB
LA  - eng
GR  - 5-T35HL07509/HL/NHLBI NIH HHS/United States
GR  - NS-22686/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Catecholamines)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
SB  - IM
MH  - Animals
MH  - Catecholamines/*physiology
MH  - Densitometry
MH  - Female
MH  - Hypoglossal Nerve/enzymology/*growth & development/*metabolism
MH  - Immunohistochemistry
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tongue/enzymology/growth & development/innervation
MH  - Tyrosine 3-Monooxygenase/metabolism
EDAT- 1996/01/22 00:00
MHDA- 1996/01/22 00:01
CRDT- 1996/01/22 00:00
PHST- 1996/01/22 00:00 [pubmed]
PHST- 1996/01/22 00:01 [medline]
PHST- 1996/01/22 00:00 [entrez]
AID - 016538069500162X [pii]
AID - 10.1016/0165-3806(95)00162-x [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 1996 Jan 22;91(1):83-92. doi: 
      10.1016/0165-3806(95)00162-x.