PMID- 8821950
OWN - NLM
STAT- MEDLINE
DCOM- 19961126
LR  - 20061115
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 9
IP  - 1
DP  - 1996 Jan
TI  - Prevalence of human papillomaviruses (HPV) in benign and malignant tumors of the 
      upper respiratory tract.
PG  - 15-20
AB  - The role for human papillomavirus (HPV) in head and neck tumors is not 
      established. To evaluate the possible role of HPV in head and neck neoplasms, 22 
      cases of laryngeal squamous papilloma (LP), 32 cases of laryngeal squamous cell 
      carcinoma (LSCC), 40 cases of nasal inverted papilloma (NIP), 14 cases of nasal 
      squamous cell carcinoma (NSCC), and 40 cases of nasopharyngeal carcinoma (NPC) 
      were evaluated for the presence of HPV DNA using the polymerase chain reaction 
      (PCR) with two sets of primers in separate reactions: HPV-L1 consensus primers, 
      HPV16 and HPV18 E7 primers for HPV nucleic acid detection. Restriction fragment 
      length polymorphism of L1 PCR product was used for typing of HPV. Overall, HPV 
      DNA was detected in 18 of 22 cases (81.8%) of LP, 3 of 32 cases (9.4%) of LSCC, 
      17 of 40 cases (42.5%) of NIP, 3 of 14 cases of NSCC (21.4%), and none of 40 
      cases of NPC. HPV6 was found more frequently in LP and HPV11 in NIP (P < 0.001). 
      In the three HPV positive LSCCs, two cases had previous LP and were HPV6 and 
      HPV11 positive, as were the prior papillomas. One other case was HPV18 positive. 
      Only HPV16 was found in the NSCC patients. There was no significant difference in 
      the index of HPV positivity between the NSCC cases associated with (16.7%) and 
      without NIP (25.6%). Our results suggest that HPV plays a role in the development 
      of both LP and NIP, and that similar viral types (i.e., HPV6 and HPV11) may 
      exhibit relative differences in their tissue specificity. HPV appears to be of 
      limited importance as a co-factor in LSCC and NPC lesions, indicating differences 
      in the pathogenesis between papillomas and carcinomas in the upper respiratory 
      tract.
FAU - Shen, J
AU  - Shen J
AD  - Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, USA.
FAU - Tate, J E
AU  - Tate JE
FAU - Crum, C P
AU  - Crum CP
FAU - Goodman, M L
AU  - Goodman ML
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Carcinoma, Squamous Cell/epidemiology/virology
MH  - DNA, Viral/analysis
MH  - Humans
MH  - Laryngeal Neoplasms/epidemiology/virology
MH  - Nasopharyngeal Neoplasms/virology
MH  - Nose Neoplasms/virology
MH  - Otorhinolaryngologic Neoplasms/epidemiology/*virology
MH  - Papilloma/epidemiology/virology
MH  - Papilloma, Inverted/virology
MH  - Papillomaviridae/*isolation & purification
MH  - Papillomavirus Infections/epidemiology
MH  - Polymorphism, Restriction Fragment Length
MH  - Prevalence
MH  - Tumor Virus Infections/epidemiology
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PST - ppublish
SO  - Mod Pathol. 1996 Jan;9(1):15-20.