PMID- 8822719
OWN - NLM
STAT- MEDLINE
DCOM- 19961101
LR  - 20190826
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 106
IP  - 9 Pt 1
DP  - 1996 Sep
TI  - Association of otitis media with effusion and allergy as demonstrated by 
      intradermal skin testing and eosinophil cationic protein levels in both middle 
      ear effusions and mucosal biopsies.
PG  - 1128-37
AB  - This study was performed to ascertain the role of allergy, as defined by skin 
      testing and histochemical markers, in the pathogenesis of otitis media with 
      effusion (OME). A historical perspective of allergy as it relates to OME is 
      presented. The study included 89 patients: 48 with persistent effusion but no 
      recent acute infection, 25 with purulent OME complicated by a superimposed 
      infection, and 16 control subjects. All 89 patients had persistent effusion for 
      more than 2 months and subsequently required the placement of tympanostomy tubes. 
      Allergy was defined using the radioallergosorbent test (RAST), serum 
      immunoglobulin E (IgE) levels, and skin tests. Allergies were present in 97% of 
      the patients with nonacute OME. The relationship between allergy and OME was 
      corroborated clinically in 89% of patients and was also substantiated by elevated 
      levels of effusion eosinophil cationic protein (ECP) in 87.5% of OME patients. 
      Histologically, polyclonal antibody staining for ECP demonstrated the presence of 
      eosinophils in middle ear mucosal biopsy specimens. This study confirms that OME 
      is a sign of allergic inflammation in the middle ear that is associated with an 
      increase in eosinophils and a concomitant release of ECP into the effusion in 
      individuals with allergy demonstrated by skin testing.
FAU - Hurst, D S
AU  - Hurst DS
AD  - Department of Clinical Chemistry, Uppsala University, Sweden.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Blood Proteins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 0 (Inflammation Mediators)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biopsy
MH  - Blood Proteins/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Eosinophil Granule Proteins
MH  - Humans
MH  - Hypersensitivity/*complications
MH  - Infant
MH  - Inflammation Mediators/*analysis
MH  - Intradermal Tests
MH  - Mucous Membrane/pathology
MH  - Otitis Media with Effusion/*immunology/pathology
MH  - Radioallergosorbent Test
MH  - *Ribonucleases
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1097/00005537-199609000-00017 [doi]
PST - ppublish
SO  - Laryngoscope. 1996 Sep;106(9 Pt 1):1128-37. doi: 
      10.1097/00005537-199609000-00017.