PMID- 8824331
OWN - NLM
STAT- MEDLINE
DCOM- 19961127
LR  - 20240216
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 16
IP  - 21
DP  - 1996 Nov 1
TI  - Expression of hepatocyte growth factor/scatter factor, its receptor, c-met, and 
      tissue-type plasminogen activator during development of the murine olfactory 
      system.
PG  - 6933-44
AB  - The expression of hepatocyte growth factor/scatter factor (HGF/SF) and its 
      receptor, the c-met proto-oncogene product, was examined by in situ hybridization 
      in the developing and adult murine olfactory system and compared with the 
      expression of a known activator of HGF/SF, tissue-type plasminogen activator 
      (tPA). In the developing olfactory canal, expression of both c-met and tPA was 
      observed in the olfactory neuroepithelium, whereas HGF/SF expression appeared to 
      be confined to the mucosa adjacent to the neuroepithelium. During development of 
      the olfactory bulb, HGF/SF and tPA were expressed within the rostral migratory 
      pathway leading to the olfactory bulb, whereas c-met expression was observed in 
      the mitral cell layer (MCL) of the olfactory bulb and in the anterior olfactory 
      nucleus. In the adult olfactory bulb, expression of HGF/SF was restricted to the 
      periglomerular region of the glomerular layer, whereas c-met was expressed in the 
      MCL and olfactory nerve fiber layers (ONL). tPA expression in the adult olfactory 
      bulb was observed in the ONL, MCL, and granule cell layers. Therefore, tPA 
      expression was relatively coincident with the expression of HGF/SF and/or c-met 
      in the appropriate projection patterns of the developing and adult olfactory 
      system. In addition, antibodies against tPA inhibited the olfactory bulb 
      extract-mediated cleavage of single-chain HGF/SF. These results suggest that tPA 
      may play a regulatory role in the development and maintenance of the olfactory 
      system by activating HGF/SF in the immediate vicinity of its receptor.
FAU - Thewke, D P
AU  - Thewke DP
AD  - Neuroscience Program and Department of Biochemistry/Biophysics and Genetics, 
      University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
FAU - Seeds, N W
AU  - Seeds NW
LA  - eng
GR  - T32 NS007083/NS/NINDS NIH HHS/United States
GR  - NS09818/NS/NINDS NIH HHS/United States
GR  - T32-NS07083/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (DNA, Complementary)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Embryo, Mammalian/physiology
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Hepatocyte Growth Factor/*genetics
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Olfactory Bulb/cytology/*embryology/*growth & development
MH  - Olfactory Receptor Neurons/physiology
MH  - Proto-Oncogene Proteins c-met
MH  - Receptor Protein-Tyrosine Kinases/*genetics
MH  - Tissue Plasminogen Activator/*genetics
PMC - PMC6579244
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
PMCR- 1997/05/01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
PHST- 1997/05/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.16-21-06933.1996 [doi]
PST - ppublish
SO  - J Neurosci. 1996 Nov 1;16(21):6933-44. doi: 10.1523/JNEUROSCI.16-21-06933.1996.