PMID- 8825716
OWN - NLM
STAT- MEDLINE
DCOM- 19961203
LR  - 20061115
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 48
IP  - 1
DP  - 1996 Jan
TI  - Seroepidemiological study of human herpesvirus-6 and -7 in children of different 
      ages and detection of these two viruses in throat swabs by polymerase chain 
      reaction.
PG  - 88-94
AB  - The presence of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) in 
      throat swabs of 62 children of different age groups (group I, ages 0-5 month; 
      group II, ages 6-11 months, group III, ages 12-23 months, group IV, age 2-8 
      years) and 28 adults was detected by polymerase chain reaction. The detection 
      rate of HHV-6 DNA was the highest (87%) in children aged 1-year-old and decreased 
      with age, whereas the detection rate of HHV-7 increased with age and reached a 
      maximum in adults. HHV-6B was detected in almost all samples except for two 
      children who secreted only HHV-6A. When the antibody prevalence was determined in 
      the four groups of children, HHV-6 antibody was detected in 8/12 (66.7%), 10/12 
      (83.3%), 15/16 (93.8%), and 13/14 (92.9%), respectively. Antibody to HHV-7 in 
      these groups was detected in 6/12 (50.0%), 4/12 (33.3%), 12/16 (75.0%), and 13/14 
      (92.9%), respectively. Detection of HHV-6 DNA in throat swabs of triplets who had 
      the sequential onset of exanthem subitum was attempted by using samples 
      sequentially collected from these children after the onset of the disease in the 
      first patient. HHV-6 DNA with high copy numbers was detectable during the acute 
      and convalescent phases of the disease in all patients, but no DNA was detected 
      in samples collected before the onset of disease.
FAU - Tanaka-Taya, K
AU  - Tanaka-Taya K
AD  - Department of Microbiology, Osaka University Medical School, Japan.
FAU - Kondo, T
AU  - Kondo T
FAU - Mukai, T
AU  - Mukai T
FAU - Miyoshi, H
AU  - Miyoshi H
FAU - Yamamoto, Y
AU  - Yamamoto Y
FAU - Okada, S
AU  - Okada S
FAU - Yamanishi, K
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/*blood
MH  - Base Sequence
MH  - Cell Line
MH  - Child
MH  - Child, Preschool
MH  - DNA, Viral/*genetics
MH  - Exanthema Subitum/pathology/*virology
MH  - Herpesviridae Infections/blood/epidemiology/*virology
MH  - Herpesvirus 6, Human/*genetics/immunology
MH  - Herpesvirus 7, Human/*genetics/immunology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Molecular Sequence Data
MH  - Pharynx/pathology/*virology
MH  - Polymerase Chain Reaction/*methods
MH  - Sensitivity and Specificity
MH  - Tumor Cells, Cultured
EDAT- 1996/01/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1002/(SICI)1096-9071(199601)48:1<88::AID-JMV14>3.0.CO;2-2 [pii]
AID - 10.1002/(SICI)1096-9071(199601)48:1<88::AID-JMV14>3.0.CO;2-2 [doi]
PST - ppublish
SO  - J Med Virol. 1996 Jan;48(1):88-94. doi: 
      10.1002/(SICI)1096-9071(199601)48:1<88::AID-JMV14>3.0.CO;2-2.