PMID- 8828358
OWN - NLM
STAT- MEDLINE
DCOM- 19970319
LR  - 20131121
IS  - 0385-2385 (Print)
IS  - 0385-2385 (Linking)
VI  - 38
IP  - 8
DP  - 1996 Aug
TI  - [Study on the clinical effect of rhubarb on nitrogen-metabolism abnormality due 
      to chronic renal failure and its mechanism].
PG  - 379-87
AB  - It is well known that diet therapy is effective for inhibition of the advancement 
      of chronic renal failure. Rhubarb, which can improve nitrogen metabolism, may 
      allow delay in the introduction of the hemodialysis. After performing diet 
      therapy with an energy intake of 35 Kcal/kg and a salt volume of less than 7g in 
      38 cases with chronic renal failure (CRF), 5 healthy volunteers (N) and 5 cases 
      with liver cirrhosis (LC), 1.0g of rhubarb was administered orally. The blood 
      urea nitrogen (BUN) did not vary in N, decreased in cases with LC and CRF 
      (rhubarb-administered group), but increased in cases with CRF 
      (non-rhubarb-administered group). The serum creatinine (s-Cr) did not vary in N 
      and cases with LC and CRF (rhubarb-administered group), but was elevated in cases 
      with CRF (non-rhubarb-administered group). Serum methylguanidine did not vary in 
      N and cases with LC, decreased in cases with CRF (rhubarb-administered group), 
      and increased in cases with CRF (non-rhubarb-administered group). The 
      chronological level of 1/Cr in cases with CRF (rhubarb-administered group) was 
      improved. In addition to the diet therapy, administration of rhubarb inhibited 
      increase of BUN and serum creatinine in cases with chronic renal failure and was 
      effective for the reduction of uremic substances. Therefore, it was concluded 
      that rhubarb can retard the introduction-period of hemodialysis and can also 
      inhibit deterioration of the disease.
FAU - Sanada, H
AU  - Sanada H
AD  - Department of Internal Medicine III, Fukushima Medical College, Japan.
LA  - jpn
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Jinzo Gakkai Shi
JT  - Nihon Jinzo Gakkai shi
JID - 7505731
RN  - 5L0H5Q9VAG (Methylguanidine)
RN  - AYI8EX34EU (Creatinine)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Urea Nitrogen
MH  - Creatinine/blood
MH  - Humans
MH  - Kidney Failure, Chronic/*metabolism
MH  - Methylguanidine/blood
MH  - Middle Aged
MH  - Nitrogen/*metabolism
MH  - *Plants, Medicinal
MH  - *Rheum
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Jinzo Gakkai Shi. 1996 Aug;38(8):379-87.