PMID- 8828946
OWN - NLM
STAT- MEDLINE
DCOM- 19961210
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 14 Suppl 15
DP  - 1996 May-Jun
TI  - Effect of intravenous gammaglobulin on organ specific antibodies and lymphocyte 
      subsets.
PG  - S37-40
AB  - OBJECTIVE: The intravenous (i.v.) administration of immunoglobulins (Ig) has 
      resulted in clinical improvement and decreased autoantibody titers in a large 
      number of autoimmune diseases. In this study, the in vivo effects of polyvalent 
      Ig for i.v. use (IVIG) on the level and course of organ-specific antibodies and 
      lymphocyte subsets in patients with autoimmune thyroid disease (ATD) were 
      assessed. METHODS: 19 patients were treated with prednisolone (P) while 21 
      patients received IVIG. Thyroid microsomal, thyroglobulin- and 
      thyrotropin-receptor autoantibodies (Abs), as well as the lymphocyte ratio 
      CD4/CD8, were measured before and at the end of immunosuppressive therapy. 
      RESULTS: Among the patients treated with IVIG, there was a marked decrease (p < 
      0.0001) in the microsomal, thyroglobulin and TSH-receptor Abs titers. Significant 
      changes in the titers were also observed after P therapy. The lymphocyte ratio 
      dropped markedly in both groups (p < 0.0005). CONCLUSION: The significant 
      decrease in organ specific Abs in the IVIG group may be explained in terms of a 
      direct and local immunosuppressive effect of the drug on the intrathyroid 
      lymphocytes.
FAU - Kahaly, G J
AU  - Kahaly GJ
AD  - Department of Medicine III, Gutenberg-University Hospital, Mainz, Germany.
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Receptors, Thyrotropin)
RN  - 554Z48XN5E (Methimazole)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Antibody Formation/*drug effects
MH  - Autoantibodies/immunology
MH  - CD4-CD8 Ratio
MH  - Humans
MH  - Immunity, Cellular/*drug effects
MH  - Immunoglobulins, Intravenous/*pharmacology
MH  - Lymphocyte Subsets/*drug effects
MH  - Methimazole/administration & dosage
MH  - Microsomes/immunology
MH  - Prednisolone/pharmacology
MH  - Receptors, Thyrotropin/immunology
MH  - Thyroid Gland/immunology
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
PST - ppublish
SO  - Clin Exp Rheumatol. 1996 May-Jun;14 Suppl 15:S37-40.