PMID- 8831803
OWN - NLM
STAT- MEDLINE
DCOM- 19961031
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 59
IP  - 14
DP  - 1996
TI  - Effect of indomethacin on the pituitary-adrenocortical response to adrenergic 
      stimulation.
PG  - 1157-64
AB  - The role of prostaglandins (PGs) in stimulation of the 
      hypothalamic-pituitary-adrenal (HPA) axis by adrenergic agonists and 
      catecholamines was investigated in nonanesthetized rats. The cyclooxygenase and 
      PGs synthesis inhibitor indomethacin was given systemically or 
      intracerebroventricularly (icv) 15 min prior to phenylephrine (30 micrograms), 
      clonidine (10 micrograms), and isoproterenol (20 micrograms), an alpha 1-, alpha 
      2-, and beta-adrenergic receptor agonists, respectively, or noradrenaline (10 
      micrograms) and adrenaline (10 micrograms). Indomethacin given ip (2 mg/kg) or 
      icv (10 micrograms) almost abolished the increase in corticosterone secretion 
      elicited by phenylephrine, considerably reduced the response to clonidine but did 
      not markedly affect the response to isoproterenol. Pretreatment with indomethacin 
      by either route strongly suppressed the corticosterone response to noradrenaline, 
      but did not substantially affect the hormonal response to adrenaline. The above 
      data indicate that prostaglandins considerably mediate the HPA axis response to 
      central stimulation of alpha 1- and alpha 2-, but not beta-adrenergic receptors. 
      They also point to significant involvement of prostaglandins in the 
      noradrenaline-, but not adrenaline-induced HPA axis predominantly via alpha 1-and 
      alpha 2-adrenergic receptors, whereas adrenaline exerts stimulation manly via 
      beta-adrenergic receptors.
FAU - Bugajski, J
AU  - Bugajski J
AD  - Department of Physiology, Polish Academy of Sciences, Cracow, Poland.
FAU - Gadek-Michalska, A
AU  - Gadek-Michalska A
FAU - Borycz, J
AU  - Borycz J
FAU - Glod, R
AU  - Glod R
FAU - Bugajski, A J
AU  - Bugajski AJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Adrenergic Agents)
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 1WS297W6MV (Phenylephrine)
RN  - L628TT009W (Isoproterenol)
RN  - MN3L5RMN02 (Clonidine)
RN  - W980KJ009P (Corticosterone)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - XXE1CET956 (Indomethacin)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adrenal Cortex/drug effects/*physiology
MH  - Adrenergic Agents/*pharmacology
MH  - Animals
MH  - Clonidine/pharmacology
MH  - Corticosterone/blood
MH  - Cyclooxygenase Inhibitors/*pharmacology
MH  - Epinephrine/pharmacology
MH  - Indomethacin/administration & dosage/*pharmacology
MH  - Isoproterenol/pharmacology
MH  - Male
MH  - Norepinephrine/pharmacology
MH  - Phenylephrine/pharmacology
MH  - Pituitary Gland/drug effects/*physiology
MH  - Rats
MH  - Rats, Wistar
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 002432059600433X [pii]
AID - 10.1016/0024-3205(96)00433-x [doi]
PST - ppublish
SO  - Life Sci. 1996;59(14):1157-64. doi: 10.1016/0024-3205(96)00433-x.