PMID- 8832626
OWN - NLM
STAT- MEDLINE
DCOM- 19961220
LR  - 20190909
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 17
IP  - 4
DP  - 1996 Jul-Aug
TI  - On the relationship between measles virus and Alzheimer neurofibrillary tangles 
      in subacute sclerosing panencephalitis.
PG  - 527-33
AB  - We have studied the relationship between measles virus and the accumulation of 
      abnormally phosphorylated tau (PHF-tau) in nine cases of subacute sclerosing 
      panencephalitis (SSPE). By assessing the presence of viral intranuclear 
      inclusions and neurofibrillary tangles (NFT) in each case, we found no 
      correlation between presence and amount of measles virus and the numbers of 
      neurons containing PHF-tau. Immunohistochemical double labeling in a case with 
      long duration of disease and severe histopathologic change revealed no strict 
      colocalization of measles virus antigen and PHF-tau throughout different brain 
      regions. In areas containing both antigens, most neurons carrying measles virus 
      did not have a tangle and vice versa, eventhough some colocalization beyond that 
      expected by chance was observed in specific cortical areas. These results 
      indicate that, although secondary to viral infection, NFT formation in SSPE is 
      not restricted to cells carrying viral antigen. Conversely, measles virus 
      infected cells do not necessarily accumulate PHF-tau. This lack of colocalization 
      at the cellular level, throughout different brain areas and among different cases 
      suggests that the formation of NFT in SSPE is not directly induced by the 
      infectious agent. The formation of NFT in this disease appears to be elicited 
      through a specific type of tissue damage and, thus, to be an epiphenomenon. This 
      pathogenetic detail may be of interest for our understanding of the role of 
      neurofibrillary degeneration in the pathogenesis of other more frequent 
      neurodegenerative diseases with cytoskeletal pathology.
FAU - Bancher, C
AU  - Bancher C
AD  - Ludwig Boltzmann Institute of Clinical Neurobiology, Lainz Hospital, Vienna, 
      Austria.
FAU - Leitner, H
AU  - Leitner H
FAU - Jellinger, K
AU  - Jellinger K
FAU - Eder, H
AU  - Eder H
FAU - Setinek, U
AU  - Setinek U
FAU - Fischer, P
AU  - Fischer P
FAU - Wegiel, J
AU  - Wegiel J
FAU - Wisniewski, H M
AU  - Wisniewski HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Hippocampus/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Male
MH  - *Measles virus
MH  - Neurofibrillary Tangles/*pathology
MH  - Subacute Sclerosing Panencephalitis/*pathology/*virology
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - S0197458096000693 [pii]
AID - 10.1016/0197-4580(96)00069-3 [doi]
PST - ppublish
SO  - Neurobiol Aging. 1996 Jul-Aug;17(4):527-33. doi: 10.1016/0197-4580(96)00069-3.